PTEN (phosphatase and tensin homologue deleted on chromosome-10), a dual specificity
phosphatase, is a tumor suppressor gene whose inactivation has been associated with …

PTEN-mediated pathways and their association with treatment-resistant prostate cancer Page 1
© 2009 THE AUTHORS 556 JOURNAL COMPILATION © 2009 BJU INTERNATIONAL | 104 …

Inactivating PTEN mutations are commonly found in prostate cancer, resulting in an
increased activation of Akt. In this study, we investigate the role of PTEN deletion and protein …

Loss of chromosome 10q is a frequently observed genetic defect in prostate cancer.
Recently, the PTEN/MMAC1 tumor suppressor gene was identified and mapped to …

The tumor suppressor gene PTEN/MMAC-1/TEP-1 (referred to hereafter as PTEN) maps to
chromosome 10q23 and encodes a dual specificity phosphatase. The PTEN protein …

BACKGROUND The tumor suppressor PTEN regulates many biological processes. A well‐
known downstream effector of PTEN is phospho‐Akt. Although PTEN is the most frequently …

Complete inactivation of the PTEN tumor suppressor gene is extremely common in
advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost …

PTEN haploinsufficiency is common in hormone‐sensitive prostate cancer, though the
incidence of genomic deletion and its downstream effects have not been elucidated in …

Introduction: The aim of this study was to clarify the role of PTEN gene in progression of
prostate cancer. Materials and Methods: A total of 51 formalin-fixed paraffin-embedded …

Not since the discovery of p53 has another molecule received as much attention as PTEN. In
the 5 years since the discovery of PTEN, encoding a dual specificity phosphatase tumor …