Over the past several years, there has been increasing interest in understanding the basic
mechanisms underlying atrial fibrillation (AF). The rise in interest is partly related to the …

Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. As the most important risk
factor for embolic stroke, AF is associated with a high morbidity and mortality. Despite …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is
increasing with the ageing of the population. Presently available treatment options are far …

Atrial fibrillation (AF) is the most common clinical arrhythmia, and an important contributor to
cardiovascular morbidity and mortality (Kannel & Benjamin, 2008). Currently available …

Despite considerable basic research into the mechanisms of atrial fibrillation (AF), not much
progress has been made in the prognosis of patients with AF. With the exception of …

Atrial electrical and structural alterations (remodeling) have emerged as key elements in the
development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in …

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical
setting. It is associated with substantial cardiovascular morbidity and mortality. Recent …

Both, the decreased L-type Ca2+ current (ICa, L) density and increased spontaneous Ca2+
release from the sarcoplasmic reticulum (SR), have been associated with atrial fibrillation …

Background—Although downregulation of L-type Ca2+ current (I Ca, L) in chronic atrial
fibrillation (AF) is an important determinant of electrical remodeling, the molecular …

▪ Abstract Atrial fibrillation (AF) was recognized and studied extensively in the early twentieth
century, but many fundamental aspects of the arrhythmia were poorly understood until quite …