A new essential protein discovery method based on the integration of protein-protein interaction and gene expression data

M Li, H Zhang, J Wang, Y Pan - BMC systems biology, 2012 - Springer
Background Identification of essential proteins is always a challenging task since it requires
experimental approaches that are time-consuming and laborious. With the advances in high …

A new method for the discovery of essential proteins

X Zhang, J Xu, W Xiao - PloS one, 2013 - journals.plos.org
Background Experimental methods for the identification of essential proteins are always
costly, time-consuming, and laborious. It is a challenging task to find protein essentiality only …

Effective identification of essential proteins based on priori knowledge, network topology and gene expressions

M Li, R Zheng, H Zhang, J Wang, Y Pan - Methods, 2014 - Elsevier
Identification of essential proteins is very important for understanding the minimal
requirements for cellular life and also necessary for a series of practical applications, such …

Identification of essential proteins based on edge clustering coefficient

J Wang, M Li, H Wang, Y Pan - IEEE/ACM Transactions on …, 2011 - ieeexplore.ieee.org
Identification of essential proteins is key to understanding the minimal requirements for
cellular life and important for drug design. The rapid increase of available protein-protein …

Prediction of essential proteins based on overlapping essential modules

B Zhao, J Wang, M Li, F Wu… - IEEE transactions on …, 2014 - ieeexplore.ieee.org
Many computational methods have been proposed to identify essential proteins by using the
topological features of interactome networks. However, the precision of essential protein …

A topology potential-based method for identifying essential proteins from PPI networks

M Li, Y Lu, J Wang, FX Wu, Y Pan - IEEE/ACM transactions on …, 2014 - ieeexplore.ieee.org
Essential proteins are indispensable for cellular life. It is of great significance to identify
essential proteins that can help us understand the minimal requirements for cellular life and …

A local average connectivity-based method for identifying essential proteins from the network level

M Li, J Wang, X Chen, H Wang, Y Pan - Computational biology and …, 2011 - Elsevier
Identifying essential proteins is very important for understanding the minimal requirements of
cellular survival and development. Fast growth in the amount of available protein–protein …

A novel essential protein identification method based on PPI networks and gene expression data

J Zhong, C Tang, W Peng, M Xie, Y Sun, Q Tang… - BMC …, 2021 - Springer
Background Some proposed methods for identifying essential proteins have better results by
using biological information. Gene expression data is generally used to identify essential …

UDoNC: an algorithm for identifying essential proteins based on protein domains and protein-protein interaction networks

W Peng, J Wang, Y Cheng, Y Lu… - IEEE/ACM transactions …, 2014 - ieeexplore.ieee.org
Prediction of essential proteins which are crucial to an organism's survival is important for
disease analysis and drug design, as well as the understanding of cellular life. The majority …

Random walk based method to identify essential proteins by integrating network topology and biological characteristics

X Lei, X Yang, H Fujita - Knowledge-Based Systems, 2019 - Elsevier
Essential proteins are regarded as the fundamental components of living organisms. The
identification of essential proteins greatly contributes to the understanding of cellular …