Over the past decade major advances have been made in our understanding of the
molecular machinery that mammalian cells use to sense and to adapt to a low-oxygen …

The role of hypoxia, increased oxygen consumption, and hypox... : Current Opinion in
Nephrology and Hypertension The role of hypoxia, increased oxygen consumption, and …

Hypoxia plays a crucial role in the pathophysiology of acute kidney injury (AKI) and
presumably also chronic kidney disease (CKD). Hypoxia‐inducible factor (HIF) is the master …

Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

All metazoan organisms are committed to respiration, using oxygen as the terminal electron
acceptor in a reaction that is carried out by cytochrome c oxidase. The consequence is that …

Analysis of oxygen sensitive pathways that regulate the hypoxia inducible factor (HIF)
transcriptional system has revealed a novel role for oxygenases in signalling hypoxia. The …

When humans are exposed to hypoxia, systemic and intracellular changes operate together
to minimise hypoxic injury and restore adequate oxygenation. Emerging evidence indicates …

Iron is required for efficient oxygen transport, and hypoxia signaling links erythropoiesis with
iron homeostasis. Hypoxia induces a highly conserved signaling pathway in cells under …

Hypoxia induces tissue-specific gene products such as erythropoietin (EPO) and vascular
endothelial growth factor (VEGF), which improve the peripheral O 2 supply, and glucose …

Oxygen (O 2) is an essential nutrient that serves as a key substrate in cellular metabolism
and bioenergetics. In a variety of physiological and pathological states, organisms …