Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

Recent advances in genetics and neuropathology support the idea that amyotrophic lateral
sclerosis (ALS) and frontotemporal lobar dementia (FTD) are two ends of a disease …

It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Amyotrophic lateral sclerosis (ALS) is an aggressive and uniformly fatal degenerative
disease of the motor nervous system. In order to understand underlying disease …

The number of patients with neurodegenerative diseases is increasing significantly
worldwide. Thus, intense research is being pursued to uncover mechanisms of disease …

Adult-onset neurodegenerative diseases are among the most difficult human health
conditions to model for drug development. Most genetic or toxin-induced cell and animal …

The ability to reprogram adult somatic cells into pluripotent stem cells that can differentiate
into all three germ layers of the developing human has fundamentally changed the …

The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …

Among the disciplines of medicine, the study of neurological disorders is particularly
challenging. The fundamental inaccessibility of the human neural types affected by disease …

Modeling amyotrophic lateral sclerosis (ALS) with human induced pluripotent stem cells
(iPSCs) aims to reenact embryogenesis, maturation and aging of spinal motor neurons …