Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and
antisense oligonucleotide (ASO), are powerful gene regulators, which have been …

The use of nucleic acid to control the expression of genes relevant to tumor progression is a
key therapeutic approach in cancer research. Therapeutics based on nucleic acid provide …

Cancer remains a major global health challenge. Traditional chemotherapy often results in
side effects and drug resistance, necessitating the development of alternative treatment …

Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer.
However, the curative effect of siRNA is severely constrained by low serum stability and cell …

The utilization of nanotechnology is one of the fast-growing scientific discoveries that
significantly affect our daily lives, especially its application in nanomedicine and targeted …

Mesoporous silica nanoparticles have attracted much attention in recent years as drug and
gene delivery systems for biomedical applications. Among their most beneficial features for …

Virus-mediated gene delivery has been, to date, the most successful and efficient method for
gene therapy. However, this method has been challenged because of serious safety …

Mesoporous silica nanoparticles (MSNs) are attracting increasing interest for potential
biomedical applications. With tailored mesoporous structure, huge surface area and pore …

Among various nanoparticles, the silica nanoparticle (SiNP) is an attractive candidate as a
gene delivery carrier due to advantages such as availability in porous forms for …

Novel mesoporous silica nanoparticles (LPMSNs) functionalised with degradable poly (2-
dimethylaminoethyl acrylate)(PDMAEA) have been developed (PDMAEA–LPMSNs) as …