Untold new beginnings: adult hippocampal neurogenesis and Alzheimer's disease

CM Teixeira, N Pallas-Bazarra, M Bolós… - Journal of …, 2018 - content.iospress.com
Neurogenesis occurs in a limited number of brain regions during adulthood. Of these, the
hippocampus has attracted great interest due to its involvement in memory processing …

[HTML][HTML] Reconsidering hippocampal neurogenesis in Alzheimer's disease

A Martinez-Canabal - Frontiers in neuroscience, 2014 - frontiersin.org
Hippocampal neurogenesis is often thought to be necessary to maintain hippocampus-
dependent cognitive abilities (see references in Deng et al., 2010). Most investigations using …

Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease

H Liu, H Zhang, Y Ma - Mechanisms of ageing and development, 2021 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia globally. AD is a
progressive neurodegenerative disorder, eventually manifesting as severe cognitive …

[HTML][HTML] Adult hippocampal neurogenesis and its role in Alzheimer's disease

Y Mu, FH Gage - Molecular neurodegeneration, 2011 - Springer
The hippocampus, a brain area critical for learning and memory, is especially vulnerable to
damage at early stages of Alzheimer's disease (AD). Emerging evidence has indicated that …

[HTML][HTML] Does impairment of adult neurogenesis contribute to pathophysiology of Alzheimer's disease? A still open question

DD Li Puma, R Piacentini, C Grassi - Frontiers in molecular …, 2021 - frontiersin.org
Adult hippocampal neurogenesis is a physiological mechanism contributing to hippocampal
memory formation. Several studies associated altered hippocampal neurogenesis with …

Adult hippocampal neurogenesis in Alzheimer's disease: an overview of human and animal studies with implications for therapeutic perspectives aimed at memory …

S Farioli-Vecchioli, V Ricci, S Middei - Neural Plasticity, 2022 - Wiley Online Library
The mammalian hippocampal dentate gyrus is a niche for adult neurogenesis from neural
stem cells. Newborn neurons integrate into existing neuronal networks, where they play a …

Compensation for neurodegeneration by hippocampal neurogenesis in Alzheimer's disease: Where is the way?

J Zheng, Y Li - Neuroscience Bulletin, 2021 - Springer
Neurodegeneration, a defining hallmark of Alzheimer's disease (AD), features the
progressive loss of neuronal structure and functions. Therapeutic approaches to AD show …

[HTML][HTML] Alzheimer's disease and hippocampal adult neurogenesis; exploring shared mechanisms

C Hollands, N Bartolotti, O Lazarov - Frontiers in neuroscience, 2016 - frontiersin.org
New neurons incorporate into the granular cell layer of the dentate gyrus throughout life.
Neurogenesis is modulated by behavior and plays a major role in hippocampal plasticity …

Neurobiological mechanisms involved in the pathogenesis of Alzheimer's disease

FA Mir, ZA Rizvi - Biological, Diagnostic and Therapeutic Advances in …, 2019 - Springer
A lzheimer's disease (AD) is one of the many neurodegenerative disorders which is
characterized by progressive loss of neurons due to the extracellular accumulation of …

Neurogenesis in human hippocampus: implications for Alzheimer disease pathogenesis

RJ Castellani, X Zhu, HG Lee, G Perry… - Neuroembryology and …, 2006 - karger.com
Hippocampal neurogenesis, the innate capacity of stem cells in the hippocampus to
generate new neurons throughout life, is attracting interest in neurodegenerative disease …