Stress proteins, including the 70 kD heat shock protein (HSP70), are induced in injured
cells. The present study was designed to characterize the cells injured by global ischemia in …

In response to many environmental and pathophysiologic stressful stimuli, cells undergo a
stress response characterized by induction of a variety of proteins, including the heat shock …

Recently, preinduction of the heat shock response has been shown to protect CNS neurons
undergoing various stressful insults, eg, heat, ischemia, or exposure to excitotoxins …

Publisher Summary This chapter focuses on the pathological significance of heat shock
protein (HSP) response in the central nervous system (CNS) following heat stress in in vivo …

The hsp70 gene is induced by denatured protein in injured cells and is an extremely
sensitive and reliable marker of cells injured by ischemia, seizures, and toxins. Normal …

Induction of hsp70 heat shock protein (HSP70) and hsp70 mRNA was examined using
adjacent sections in the same rat brain following permanent middle cerebral artery (MCA) …

Heat shock proteins (hsps) are involved in the response by cells to stress including
hyperthermia, hypoxia and injury. Previous work has demonstrated expression of …

Regional localization of HSP70 expression in brain of rats exposed to increased ambient
temperatures was examined using in situ hybridization. In addition to the cerebellar granule …

In situ hybridization reveals striking regional differences in the expression of constitutive and
inducible heat shock genes in the rabbit brain. Fibre tracts throughout the brain show a …

This study attempted to ascertain whether the ischemic damage to neurons and monoamine
overload in brain that occur during rat heatstroke can be attenuated by heat shock protein …