Small animal models of chronic obstructive pulmonary disease (COPD) have several
limitations for identifying new therapeutic targets and biomarkers for human COPD. These …

Pulmonary emphysema is a major component of the morbidity and mortality of chronic
obstructive pulmonary disease (COPD). Currently there are no predictive biomarkers for …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide, and its global health burden is increasing. COPD is characterized by …

Chronic exposure of laboratory animals to cigarette smoke reproduces many of the
anatomic/physiologic lesions (emphysema, small-airway remodeling and pulmonary …

Animal model of cigarette smoke (CS)–induced chronic obstructive pulmonary disease
(COPD) is the primary testing methodology for drug therapies and studies on pathogenic …

COPD can manifest itself with different clinical phenotypes characterized by different
disease progression and response to therapy. Although a remarkable number of studies …

Objectives To review the animal models of COPD, and to compare these data to those found
in humans. Results Smoke-induced animal models can produce emphysema, although the …

Cigarette smoke (CS)-exposed mice have been used to model airway inflammation and
emphesema in humans; however, the impact of exposure duration, sex, and strain …

Mouse models of chronic obstructive pulmonary disease (COPD) focus on airway
inflammation and lung histology, but their use has been hampered by the lack of pulmonary …

Chronic obstructive pulmonary disease (COPD) is one of the most important threats to public
health because of its prevalence, economic cost, and impact on death and disability …