NLR in eXile: Emerging roles of NLRX1 in immunity and human disease
RJ Pickering, LM Booty - Immunology, 2021 - Wiley Online Library
NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …
[HTML][HTML] Behind the scenes: nod-like receptor X1 controls inflammation and metabolism
Regulatory Nod-like receptors (NLRs) are a subgroup of the cytosolic NLR family of
pathogen recognition receptors (PRRs). These receptors can tune the innate immune …
pathogen recognition receptors (PRRs). These receptors can tune the innate immune …
The regulatory role of NLRX1 in innate immunity and human disease
M Liu, K Liu, D Cheng, B Zheng, S Li, Z Mo - Cytokine, 2022 - Elsevier
Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …
NLRX1 is a mitochondrial NOD‐like receptor that amplifies NF‐κB and JNK pathways by inducing reactive oxygen species production
I Tattoli, LA Carneiro, M Jéhanno, JG Magalhaes… - EMBO …, 2008 - embopress.org
NOD‐like receptors (NLRs) are a family of intracellular sensors of microbial‐or danger‐
associated molecular patterns. Here, we report the identification of NLRX1, which is a new …
associated molecular patterns. Here, we report the identification of NLRX1, which is a new …
[HTML][HTML] NLRX1 is a multifaceted and enigmatic regulator of immune system function
Over the last decade, significant progress has been achieved in defining mechanisms
underlying NLR regulation of immune system function. However, several NLR family …
underlying NLR regulation of immune system function. However, several NLR family …
Focusing on the cell type specific regulatory actions of NLRX1
Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect
exogenous or endogenous danger signals and even the changes of their microenvironment …
exogenous or endogenous danger signals and even the changes of their microenvironment …
[HTML][HTML] Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in inflammatory bowel disease
HA Morrison, B Trusiano, AJ Rowe, IC Allen - biomedical journal, 2023 - Elsevier
A subset of NLRs function to mitigate overzealous pro-inflammatory signaling produced by
NF-κB activation. Under normal pathophysiologic conditions, proper signaling by these …
NF-κB activation. Under normal pathophysiologic conditions, proper signaling by these …
[PDF][PDF] The innate immune receptor NLRX1 functions as a tumor suppressor by reducing colon tumorigenesis and key tumor-promoting signals
AA Koblansky, AD Truax, R Liu, SA Montgomery… - Cell reports, 2016 - cell.com
NOD-like receptor (NLR) proteins are intracellular innate immune sensors/receptors that
regulate immunity. This work shows that NLRX1 serves as a tumor suppressor in colitis …
regulate immunity. This work shows that NLRX1 serves as a tumor suppressor in colitis …
[HTML][HTML] NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation
The role of mitochondria is emerging in regulation of innate immunity, inflammation and cell
death beyond its primary role in energy metabolism. Mitochondria act as molecular platform …
death beyond its primary role in energy metabolism. Mitochondria act as molecular platform …
A functional role for Nlrp6 in intestinal inflammation and tumorigenesis
The nucleotide-binding oligomerization domain-like receptor (NLR) family member, Nlrp6,
has been implicated in inflammasome signaling to activate caspase-1, which is essential for …
has been implicated in inflammasome signaling to activate caspase-1, which is essential for …