T cell memory relies on the generation of antigen-specific progenitors with stem-like
properties. However, the identity of these progenitors has remained unclear, precluding a …

The developmental origins of memory T cells remain incompletely understood. During the
expansion phase of acute viral infection, we identified a distinct subset of virus-specific …

Memory CD8 T cells provide durable protection against diverse intracellular pathogens and
can be broadly segregated into distinct circulating and tissue-resident populations …

CD8+ T cell immunological memory of past antigen exposure can confer long-lived
protection against infections or tumors. The fact that CD8+ memory T cells can have features …

Mechanisms for the generation of memory CD4 T cells and their delineation into diverse
subsets remain largely unknown. In this study, we demonstrate in two Ag systems, divergent …

Clonal expansion is a core aspect of T cell immunity. However, little is known with respect to
the relationship between replicative history and the formation of distinct CD8+ memory T cell …

In response to infection or effective vaccination, naive antigen‐specific CD8+ T cells
undergo a dramatic highly orchestrated activation process. Initial encounter with an …

Abstract Naive CD4+ and CD8+ T cells undergo unique developmental programs after
activation, resulting in the generation of effector and long-lived memory T cells. Recent …

Memory CD8+ T-cell development is defined by the expression of a specific set of memory
signature genes. Despite recent progress, many components of the transcriptional control of …

Highlights•The effector and memory CD8+ T cell populations exhibit significant
heterogeneity.•Effector and memory T cell subsets exist in 'states' and retain some degree of …