Ly6CLo monocyte/macrophages are essential for thrombus resolution in a murine model of venous thrombosis

AS Kimball, AT Obi, CE Luke… - Thrombosis and …, 2020 - thieme-connect.com
Venous thrombosis (VT) resolution is a complex process, resembling sterile wound healing.
Infiltrating blood-derived monocyte/macrophages (Mo/MΦs) are essential for the regulation …

Matrix metalloproteinase 9 (MMP-9) regulates vein wall biomechanics in murine thrombus resolution

KP Nguyen, KC McGilvray, CM Puttlitz… - PloS one, 2015 - journals.plos.org
Objective Deep venous thrombosis is a common vascular problem with long-term
complications including post-thrombotic syndrome. Post-thrombotic syndrome consists of leg …

Endothelial progenitor cells accelerate the resolution of deep vein thrombosis

WD Li, XQ Li - Vascular pharmacology, 2016 - Elsevier
Deep vein thrombosis (DVT) causes high morbidity and mortality. Successful resolution of
DVT-related thrombi is the key point in the treatment of DVT. Recently, endothelial …

Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice

M Nosaka, Y Ishida, A Kimura… - The Journal of …, 2011 - Am Soc Clin Investig
Deep vein thrombosis (DVT) is a major cause of pulmonary thromboembolism, a leading
cause of death in individuals with DVT. Several lines of evidence indicate proinflammatory …

Incomplete resolution of deep vein thrombosis under reduced flow conditions

BC Cooley, CY Chen, R Hess, G Schmeling - Thrombosis research, 2013 - Elsevier
INTRODUCTION: Post-thrombotic syndrome is a major complication of deep vein
thrombosis (DVT), occurring in up to 1/3 of first-episode DVT patients. Non-ambulatory …

Urokinase plasminogen activator independent early experimental thrombus resolution: MMP2 as an alternative mechanism

V Sood, CE Luke, J Baldwin, EM Miller… - Thrombosis and …, 2010 - thieme-connect.com
Deep-vein thrombosis (DVT) resolution is thought to be primarily a urokinase plasminogen
activator (uPA)-dependent mechanism, although observations suggest other non-fibrinolytic …

Immunothrombosis and the role of platelets in venous thromboembolic diseases

M Heestermans, G Poenou, AC Duchez… - International Journal of …, 2022 - mdpi.com
Venous thromboembolism (VTE) is the third leading cardiovascular cause of death and is
conventionally treated with anticoagulants that directly antagonize coagulation. However …

Dysregulated haemostasis in thrombo-inflammatory disease

PA Klavina, G Leon, AM Curtis, RJS Preston - Clinical Science, 2022 - portlandpress.com
Inflammatory disease is often associated with an increased incidence of venous
thromboembolism in affected patients, although in most instances, the mechanistic basis for …

Advances in understanding the molecular mechanisms of venous thrombosis

RJS Preston, JM O'Sullivan… - British journal of …, 2019 - Wiley Online Library
Venous thromboembolism (VTE) represents a leading cause of global mortality, however,
the determinants that contribute to thrombus development remain incompletely understood …

Neutrophils promote venular thrombosis by shaping the rheological environment for platelet aggregation

D Puhr-Westerheide, SJ Schink, M Fabritius… - Scientific reports, 2019 - nature.com
In advanced inflammatory disease, microvascular thrombosis leads to the interruption of
blood supply and provokes ischemic tissue injury. Recently, intravascularly adherent …