[HTML][HTML] Neutrophil extracellular traps mediate deep vein thrombosis: From mechanism to therapy

M Yao, J Ma, D Wu, C Fang, Z Wang, T Guo… - Frontiers in …, 2023 - frontiersin.org
Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically
manifests as swelling and pain in the lower limbs. The most serious clinical complication of …

[HTML][HTML] Insights into immunothrombosis: the interplay among neutrophil extracellular trap, von Willebrand factor, and ADAMTS13

J Yang, Z Wu, Q Long, J Huang, T Hong… - Frontiers in …, 2020 - frontiersin.org
Both neutrophil extracellular traps (NETs) and von Willebrand factor (VWF) are essential for
thrombosis and inflammation. During these processes, a complex series of events, including …

[HTML][HTML] Intact Toll-like receptor 9 signaling in neutrophils modulates normal thrombogenesis in mice

OM El-Sayed, NA Dewyer, CE Luke, M Elfline… - Journal of vascular …, 2016 - Elsevier
Background Deletion of Toll-like receptor 9 (Tlr9) signaling, which is important for sterile
inflammatory processes, results in impaired resolution of venous thrombosis (VT) in mice …

Stenosis of the inferior vena cava: a murine model of deep vein thrombosis

H Payne, A Brill - JoVE (Journal of Visualized Experiments), 2017 - jove.com
Deep vein thrombosis (DVT) and its devastating complication, pulmonary embolism, are a
severe health problem with high mortality. Mechanisms of thrombus formation in veins …

Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle

T Dehghani, A Panitch - Open biology, 2020 - royalsocietypublishing.org
Severe fibrotic and thrombotic events permeate the healthcare system, causing suffering for
millions of patients with inflammatory disorders. As late-state consequences of chronic …

Assessment of venous thrombosis in animal models

SP Grover, CE Evans, AS Patel, B Modarai… - … , and vascular biology, 2016 - Am Heart Assoc
Deep vein thrombosis and common complications, including pulmonary embolism and post-
thrombotic syndrome, represent a major source of morbidity and mortality worldwide …

[HTML][HTML] A vein wall cell atlas of murine venous thrombosis determined by single-cell RNA sequencing

E DeRoo, T Zhou, H Yang, A Stranz, P Henke… - Communications …, 2023 - nature.com
Deep vein thrombosis (DVT) is a common clinical problem, but its cellular and molecular
mechanisms remain incompletely understood. In this study, we performed single-cell RNA …

[HTML][HTML] The mechanistic and structural role of von Willebrand factor in endotoxemia-enhanced deep vein thrombosis in mice

SJ Choi, CN Dwyer, L Rapkin, M Cormier… - Journal of Thrombosis …, 2023 - Elsevier
Background Although the concept of immunothrombosis has established a link between
inflammation and thrombosis, the role of inflammation in the pathogenesis of deep vein …

The vessel wall: A forgotten player in post thrombotic syndrome

S DeRoo, KB Deatrick, PK Henke - Thrombosis and …, 2010 - thieme-connect.com
Much research in venous thrombotic diseases focuses on the acute thrombotic process such
as anticoagulation and risk factors. Deep-vein thrombosis directly leads to post thrombotic …

Deep vein thrombosis: Current status and nanotechnology advances

AS Wadajkar, S Santimano, M Rahimi, B Yuan… - Biotechnology …, 2013 - Elsevier
Deep vein thrombosis (DVT) affects up to 2 million people in the United States, and
worldwide incidence is 70 to 113 cases per 100,000 per year. Mortality from DVT is often …