Inflammation, infection and venous thromboembolism

ME Colling, BE Tourdot, Y Kanthi - Circulation research, 2021 - Am Heart Assoc
The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

The emerging role of NETs in venous thrombosis and immunothrombosis

AS Kimball, AT Obi, JA Diaz, PK Henke - Frontiers in immunology, 2016 - frontiersin.org
Venous thrombosis (VT), a leading cause of morbidity and mortality worldwide, has recently
been linked to neutrophil activation and release of neutrophil extracellular traps (NETs) via a …

Specialized regulatory T cells control venous blood clot resolution through SPARC

F Shahneh, A Grill, M Klein… - Blood, The Journal …, 2021 - ashpublications.org
The cells and mechanisms involved in blood clot resorption are only partially known. We
show that regulatory T cells (Tregs) accumulate in venous blood clots and regulate …

Endothelial cells: source, barrier, and target of defensive mediators

LT Roumenina, J Rayes, M Frimat… - Immunological …, 2016 - Wiley Online Library
Endothelium is strategically located at the interface between blood and interstitial tissues,
placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are …

Novel biomarkers associated with deep venous thrombosis: a comprehensive review

DM Barnes, TW Wakefield… - Biomarker …, 2008 - journals.sagepub.com
Primary and recurrent venous thromboembolic disease (VTE, deep venous thrombosis and
pulmonary embolism) remain a significant source of morbidity and mortality in the …

By word of mouse: using animal models in venous thrombosis research

J Campos, A Brill - Platelets, 2020 - Taylor & Francis
Deep vein thrombosis (DVT) is a disease with high prevalence and morbidity. It can lead to
pulmonary embolism with severe respiratory insufficiency and risk of death. Mechanisms …

Venous thromboembolism: thrombosis, inflammation, and immunothrombosis for clinicians

E Vazquez-Garza, C Jerjes-Sanchez… - Journal of thrombosis …, 2017 - Springer
Venous thromboembolism (VTE) is a worldwide disease related with mortality,
cardiovascular disability, impaired quality of life and, cause major long-term complications …

Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model

PK Henke, CG Pearce, DM Moaveni… - The Journal of …, 2006 - journals.aai.org
CCR2 is required for monocyte recruitment in many inflammatory processes, as well as
conferring Th1 lymphokine responses. Deep vein thrombosis (DVT) resolution represents a …

Thromboinflammation: from atherosclerosis to COVID-19

DD Wagner, LA Heger - Arteriosclerosis, thrombosis, and vascular …, 2022 - Am Heart Assoc
The activating interplay of thrombosis and inflammation (thromboinflammation) has been
established as a major underlying pathway, driving not only cardiovascular disease but also …

New insights into the mechanisms of venous thrombosis

N Mackman - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Venous thrombosis is a leading cause of morbidity and mortality in industrialized countries,
especially in the elderly. Many risk factors have been identified for venous thrombosis that …