Tumor emboli were produced in lungs of Sprague-Dawley rats by iv injection of Walker 256
tumor cells into the tail vein. Tissues were examined by electron microscopy at periods from …

Sections of human tumors have been stained for fibrin deposits by the fluorescein label
technic. Large clots of extravascular fibrin were demonstrated in most of the tumors tested …

In view of the possible role of platelets and coagulation mechanisms in the growth and
dissemination of solid tumors, a number of hematological parameters were followed during …

A volume of data that has accumulated for over a century has suggested that fibrin may
facilitate the persistence and progression of malignancy. Techniques that have been …

Abstract 125I-radiolabeled guinea pig fibrinogen was used to measure the influx (20 min)
and accumulation (18 h) of fibrinogen/fibrin in three transplantable carcinomas (Lewis lung …

With the aid of radioisotopic and indirect immunofluorescence techniques, human fibrinogen
and urokinase-activated human plasmin were found to localize in transplanted Murphy …

Studies on the role of fibrin in experimental cancer growth should take into account the
following problems: 1) during growth and dissemination of experimental tumours …

The mechanism of coagulation activation in renal cell carcinoma was investigated using
immunohistochemical techniques applied to fresh frozen sections of resected primary …

METHODS Fibrin plates were prepared by placing 15 nil. of the fibrinogen solution in a small
petii dish (5-cm. diameter) to which was added 0.1 ml. thrombin solution. In the first series of …

Detailed studies tumor cell-associated procoagulants and fibrinolytic factors have strongly
suggested that local thrombin and plasmin generation may be important in tumor …