Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic
progression remain poorly understood. We isolated pure populations of cancer cells from …

The extent to which early events shape tumor evolution is largely uncharacterized, even
though a better understanding of these early events may help identify key vulnerabilities in …

Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor type that is
typically metastatic upon diagnosis. We have a poor understanding of the factors that control …

Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor, and no effective
treatment is available to date. Mouse models of SCLC based on the inactivation of Rb1 and …

INTRODUCTION Cancer is one of the leading causes of death worldwide. Although the 2%
of the human genome that encodes proteins has been extensively studied, much remains to …

Tissue homeostasis and regeneration rely on resident stem cells (SCs), whose behaviour is
regulated through niche-dependent crosstalk. The mechanisms underlying SC identity are …

For many solid malignancies, lymph node (LN) involvement represents a harbinger of
distant metastatic disease and, therefore, an important prognostic factor. Beyond its utility as …

Molecular subtypes of small cell lung cancer (SCLC) defined by the expression of key
transcription regulators have recently been proposed in cell lines and limited number of …

While invasion and metastasis of tumour cells are the principle factor responsible for cancer
related deaths, the mechanisms governing the process remain poorly defined. Moreover …

Metastatic colonization relies on interactions between disseminated cancer cells and the
microenvironment in secondary organs. Here, we show that disseminated breast cancer …