Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1

ZJ Miknis, E Magracheva, W Li, A Zdanov… - Journal of molecular …, 2010 - Elsevier
Interferon (IFN)-λ1 [also known as interleukin (IL)-29] belongs to the recently discovered
group of type III IFNs. All type III IFNs initiate signaling processes through formation of …

The structure of human interferon lambda and what it has taught us

HH Gad, OJ Hamming, R Hartmann - Journal of Interferon & …, 2010 - liebertpub.com
Type III interferon (IFN) or IFN-λ is a novel family of class II cytokines that induces antiviral
activities both in vitro and in vivo through its own distinctive receptor complex. The recent …

Human interferon-λ3 is a potent member of the type III interferon family

C Dellgren, HH Gad, OJ Hamming, J Melchjorsen… - Genes & …, 2009 - nature.com
Type III interferon (IFN) or IFN-λ is a recently discovered family of IFNs that signal through
the same downstream transcription factors as type I IFN but use a separate receptor complex …

[HTML][HTML] Interferon-λ is functionally an interferon but structurally related to the interleukin-10 family

HH Gad, C Dellgren, OJ Hamming, S Vends… - Journal of Biological …, 2009 - ASBMB
Interferon-λ (IFN-λ) is an antiviral cytokine that signals through a distinct receptor complex,
composed of the IFN-λR1 and interleukin-10R2 (IL-10R2) receptor chains. We have …

[HTML][HTML] The IFN-λ-IFN-λR1-IL-10Rβ complex reveals structural features underlying type III IFN functional plasticity

JL Mendoza, WM Schneider, HH Hoffmann… - Immunity, 2017 - cell.com
Type III interferons (IFN-λs) signal through a heterodimeric receptor complex composed of
the IFN-λR1 subunit, specific for IFN-λs, and interleukin-10Rβ (IL-10Rβ), which is shared by …

Interferon-lambda: a new addition to an old family

RP Donnelly, SV Kotenko - Journal of Interferon & Cytokine …, 2010 - liebertpub.com
The discovery and initial description of the interferon-λ (IFN-λ) family in early 2003 opened
an exciting new chapter in the field of IFN research. There are 3 IFN-λ genes that encode 3 …

Determination of the human type I interferon receptor binding site on human interferon‐α2 by cross saturation and an NMR‐based model of the complex

SR Quadt‐Akabayov, JH Chill, R Levy… - Protein …, 2006 - Wiley Online Library
Type I interferons (IFNs) are a family of homologous helical cytokines that exhibit pleiotropic
effects on a wide variety of cell types, including antiviral activity and antibacterial …

Structural analysis of cytokines comprising the IL-10 family

A Zdanov - Cytokine & growth factor reviews, 2010 - Elsevier
Interleukin-10 (IL-10) family of cytokines includes a number of its viral homologs and eight
cellular cytokines (IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29). The latter three …

The EM structure of a type I interferon–receptor complex reveals a novel mechanism for cytokine signaling

Z Li, JJ Strunk, P Lamken, J Piehler, T Walz - Journal of molecular biology, 2008 - Elsevier
Type I interferons (IFNs) have pleiotropic effects, including antiviral, antiproliferative, and
immunomodulatory responses. All type I IFNs bind to a shared receptor consisting of the two …

[HTML][HTML] Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2

SN Chen, Z Gan, J Hou, YC Yang, L Huang… - Nature …, 2022 - nature.com
Interferons (IFNs) are critical soluble factors in the immune system and are composed of
three types,(I, II and III) that utilize different receptor complexes IFN-αR1/IFN-αR2, IFN …