Somatotropic‐Testicular Axis: A crosstalk between GH/IGF‐I and gonadal hormones during development, transition, and adult age

M Tenuta, F Carlomagno, B Cangiano, G Kanakis… - …, 2021 - Wiley Online Library
Background The hypothalamic‐pituitary‐gonadal (HPG) and hypothalamic‐pituitary‐
somatotropic (HPS) axes are strongly interconnected. Interactions between these axes are …

Testicular growth and pubertal onset in GH-deficient children treated with growth hormone: a retrospective study

R Cannarella, M Caruso, A Crafa… - Frontiers in …, 2021 - frontiersin.org
The prevalence of idiopathic oligozoospermia has been esteemed as high as 75%. An
Italian survey has reported bilateral testicular hypotrophy in 14% of final-year high school …

Why do normal children have acromegalic levels of IGF-I during puberty?

A Juul, NE Skakkebæk - The Journal of Clinical Endocrinology & …, 2019 - academic.oup.com
Context The rapid pubertal height growth is unique to humans, but why do we have it?
Although the spurt contributes 13% to 15% to the final adult height, we hypothesized that the …

Common features and differences of the hypothalamic–pituitary–gonadal axis in male and female

T Dagklis, K Ravanos, K Makedou… - Gynecological …, 2015 - Taylor & Francis
Male and female reproductive axis, comprised of hypothalamus, pituitary and gonads,
present common features and differences, discussed in this review. These include the way …

Puberty is delayed in male growth hormone receptor gene—disrupted mice

DE Keene, MO Suescun, MG Bostwick… - Journal of …, 2002 - Wiley Online Library
The role of insulin‐like growth factor‐I (IGF‐I) in the initiation of puberty and testicular
function is poorly understood. Growth hormone (GH) receptor (R) gene‐disrupted mice or …

Effects of growth hormone replacement therapy on IGF-related parameters and on the pituitary-gonadal axis in GH-deficient males: a double-blind, placebo-controlled …

A Juul, AM Andersson, SA Pedersen… - Hormone Research in …, 1998 - karger.com
It has been suggested that growth hormone (GH) may play a regulatory role in male
reproductive function. To express full anabolic effect in immature boys testosterone …

Molecular regulation of hypothalamus–pituitary–gonads axis in males

JM Jin, WX Yang - Gene, 2014 - Elsevier
The hypothalamic–pituitary–gonadal axis (HPG) plays vital roles in reproduction and steroid
hormone production in both sexes. The focus of this review is upon gene structures, receptor …

[PDF][PDF] Hypothalamus-PituitaryGonadal axis: It is time for revision

B Asimakopoulos - Hum Genet Embryol, 2012 - academia.edu
The structure and the function of the Hypothalamus-Pituitary-Gonadal (HPG) axis is an
integral part of the knowledge on the physiology of the human body that every bioscientist …

Postnatal changes in testicular position are associated with IGF-I and function of Sertoli and Leydig cells

JJ Koskenniemi, HE Virtanen… - The Journal of …, 2018 - academic.oup.com
Context Despite clinical guidelines calling for repetitive examination of testicular position
during childhood, little is known of normal changes in testicular position during childhood, let …

Regulation of testicular insulin-like growth factor-I in pubertal growth hormone-deficient male rats

J Spiteri-Grech, JMS Bartlett… - Journal of …, 1991 - joe.bioscientifica.com
ABSTRACT GH plays a major role in pubertal growth, effects mainly mediated by stimulation
of insulin-like growth factor-I (IGF-I) production by the liver. However, the role of GH in the …