Background and objective Renal tissue injuries by free radicals are an essential reason in
pathogenesis of urinary tract stones. Ethylene glycol is one of the toxic agents which can …

Objective: The study aimed to evaluate the preventive effects of hydroxycitric acid (HCA) for
stone formation in the glyoxylate-induced mouse model. Materials and Methods: Male …

Background. Nephrolithiasis is a common disease that seriously affects the health and life
quality of patients. Despite the reported effect of hyperoside (Hyp) against nephrolithiasis …

Nephrolithiasis is a common and frequently-occurring disease in the urinary system with
high recurrence. The present study aimed to explore the protective effect and underlying …

This study was aimed to investigate the preventive effects of N-acetyl-l-cysteine (NAC)
against renal tubular cell injury induced by oxalate and stone formation and further explore …

Purpose Renal epithelial cell injury by reactive oxygen species is a prerequisite step in the
pathogenesis of urolithiasis, and there is increasing evidence that reactive oxygen species …

Abstract Aims Apigenin (4′, 5, 7-trihydroxyflavone) is one of the subclasses of flavonoids
and has various pharmacological effects. The present work was carried out to study the …

Objective To investigate the protective effect and mechanism of Klotho protein on oxidative
stress in renal tubular epithelial cells of experimental rat nodels of renal calcium oxalate …

Calcium oxalate (CaOx) is the most common type of urinary stone. Increase of ROS and
NADPH oxidase gives rise to inflammation and injury of renal tubular cells, which promotes …

Oxidative stress is a major risk factor for calcium oxalate nephrolithiasis. Reports suggest
that oxidative stress response is induced in animals and humans with kidney stones. Keap1 …