Enzymatic PEGylation of oligonucleotides

A Sosic, M Pasqualin, G Pasut, B Gatto - Abstract NPCF7, 2013 - research.unipd.it
The gene and RNAi therapies as well as therapeutic aptamers attracted a great interest
owing to the potential high selectivity and the theoretical possibility to treat a wide range of …

[引用][C] DNA Catalysts with Tyrosine Kinase Activity

S Amit - 2013

[HTML][HTML] Assessing histidine tags for recruiting deoxyribozymes to catalyze peptide and protein modification reactions

CC Chu, SK Silverman - Organic & biomolecular chemistry, 2016 - pubs.rsc.org
We evaluate the ability of hexahistidine (His6) tags on peptide and protein substrates to
recruit deoxyribozymes for modifying those substrates. For two different deoxyribozymes …

DNA catalysts with tyrosine kinase activity

SM Walsh, A Sachdeva… - Journal of the American …, 2013 - ACS Publications
We show that DNA catalysts (deoxyribozymes, DNA enzymes) can phosphorylate tyrosine
residues of peptides. Using in vitro selection, we identified deoxyribozymes that transfer the …

[引用][C] Research Progress in PEGylation of Drugs

宋新蕾 - 中国生物化学与分子生物学会第十一次会员代表大会暨 …, 2014

[引用][C] TOWARDS DIRECT PEGYLATION OF TYROSINE FRAGMENTS

G Mantovani, MW Jones, DM Haddleton - Polymer Preprints, 2007

Anti-cancer PEG-enzymes: 30 years old, but still a current approach

G Pasut, M Sergi, FM Veronese - Advanced drug delivery reviews, 2008 - Elsevier
PEGylation (ie the covalent link of PEG strands) is a well known technique used to improve
pharmaceutical properties of bioactive proteins and peptides. Even in cancer therapy some …

Design and study of PEG linkers that enable robust characterization of PEGylated proteins

A Saha-Shah, S Sun, J Kong, W Zhong… - ACS Pharmacology & …, 2021 - ACS Publications
Several PEGylated therapeutic proteins are approved drugs, and more are under
development. However, the synthesis and characterization of these bioconjugates …

In vitro selection of deoxyribozymes for O-glycoside cleavage and for 3-nitrotyrosine modification

CC Yeh - 2019 - ideals.illinois.edu
Proteins and RNA are biopolymers that form complex secondary and tertiary structures and
perform catalysis in nature. Single-stranded DNA is structurally similar to RNA and is also …

[HTML][HTML] A modular tyrosine kinase deoxyribozyme with discrete aptamer and catalyst domains

V Dokukin, SK Silverman - Chemical Communications, 2014 - pubs.rsc.org
We assess the utility of integrating a predetermined aptamer DNA module adjacent to a
random catalytic DNA region for identifying new deoxyribozymes by in vitro selection. By …