PEGylation of proteins as tailored chemistry for optimized bioconjugates
G Pasut, FM Veronese - Polymer Therapeutics I, 2006 - Springer
The high potential of peptides and proteins as therapeutic agents has not been fully
exploited because of their common shortcomings: the only exist for a short lifetime in the …
exploited because of their common shortcomings: the only exist for a short lifetime in the …
Protein PEGylation, basic science and biological applications
FM Veronese, A Mero, G Pasut - … protein drugs: basic science and clinical …, 2009 - Springer
A historical overview of protein-polymer conjugation is reported here, demonstrating the
superiority of poly (ethylene glycol)(PEG) among other synthetic or natural polymers, thanks …
superiority of poly (ethylene glycol)(PEG) among other synthetic or natural polymers, thanks …
Nucleobase-modified deoxyribozymes for amide and peptide hydrolysis
C Zhou - 2018 - ideals.illinois.edu
Nature has evolved proteins and RNA as enzymes. These biopolymers can fold into
complex structures to enable catalysis. DNA is primarily double-stranded and is non …
complex structures to enable catalysis. DNA is primarily double-stranded and is non …
Research progress on chemical modifications of tyrosine residues in peptides and proteins
W Zeng, J Xue, H Geng, X Liu, J Yang… - Biotechnology and …, 2024 - Wiley Online Library
The chemical modifications (CMs) of protein is an important technique in chemical biology,
protein‐based therapy, and material science. In recent years, there has been rapid …
protein‐based therapy, and material science. In recent years, there has been rapid …
Site-selective conjugation at native amino acids
K Peciak - 2014 - discovery.ucl.ac.uk
The efficacy of protein-based medicines is frequently compromised by rapid clearance from
circulation. Achieving prolonged and optimal pharmacokinetics (PK) is necessary to avoid …
circulation. Achieving prolonged and optimal pharmacokinetics (PK) is necessary to avoid …
[引用][C] Tools for PEGylation
M Junkers - sigmaaldrich.cn
Polyethylene glycol (PEG) reagents offer numerous favorable characteristics, including high
water solubility, high mobility in solution, lack of toxicity and immunogenicity, and ready …
water solubility, high mobility in solution, lack of toxicity and immunogenicity, and ready …
[HTML][HTML] Protein PEGylation: An overview of chemistry and process considerations
VB Damodaran, C Fee - European …, 2010 - europeanpharmaceuticalreview.com
Innovative drug delivery technologies are key components of drug development, with
commercial and intellectual values. PEGylation is an excellent example of a delivery system …
commercial and intellectual values. PEGylation is an excellent example of a delivery system …
Hydrophobized PEG for unexposed aminoacid conjugation.
S Salmaso, S Bersani, F Caboi, F Selis, M Sergi… - 2007 - research.unipd.it
PEGylation has been largely applied to ameliorate the pharmacokinetic, immunological and
physicochemical properties of protein therapeutics (1). However, the therapeutic …
physicochemical properties of protein therapeutics (1). However, the therapeutic …
Site-selective protein conjugation at histidine
K Peciak, E Laurine, R Tommasi, J Choi… - Chemical …, 2019 - pubs.rsc.org
Site-selective conjugation generally requires both (i) molecular engineering of the protein of
interest to introduce a conjugation site at a defined location and (ii) a site-specific …
interest to introduce a conjugation site at a defined location and (ii) a site-specific …
Site-Specific Poly (ethylene glycol) ylation of Peptides
AM Felix - 1997 - ACS Publications
In contrast to proteins, peptides are ideal targets for PEGylation since they may be
PEGylated using modern orthogonal protection strategies. Synthetic conditions have been …
PEGylated using modern orthogonal protection strategies. Synthetic conditions have been …