The high potential of peptides and proteins as therapeutic agents has not been fully
exploited because of their common shortcomings: the only exist for a short lifetime in the …

A historical overview of protein-polymer conjugation is reported here, demonstrating the
superiority of poly (ethylene glycol)(PEG) among other synthetic or natural polymers, thanks …

Nature has evolved proteins and RNA as enzymes. These biopolymers can fold into
complex structures to enable catalysis. DNA is primarily double-stranded and is non …

The chemical modifications (CMs) of protein is an important technique in chemical biology,
protein‐based therapy, and material science. In recent years, there has been rapid …

The efficacy of protein-based medicines is frequently compromised by rapid clearance from
circulation. Achieving prolonged and optimal pharmacokinetics (PK) is necessary to avoid …

Polyethylene glycol (PEG) reagents offer numerous favorable characteristics, including high
water solubility, high mobility in solution, lack of toxicity and immunogenicity, and ready …

Innovative drug delivery technologies are key components of drug development, with
commercial and intellectual values. PEGylation is an excellent example of a delivery system …

PEGylation has been largely applied to ameliorate the pharmacokinetic, immunological and
physicochemical properties of protein therapeutics (1). However, the therapeutic …

Site-selective conjugation generally requires both (i) molecular engineering of the protein of
interest to introduce a conjugation site at a defined location and (ii) a site-specific …

In contrast to proteins, peptides are ideal targets for PEGylation since they may be
PEGylated using modern orthogonal protection strategies. Synthetic conditions have been …