[HTML][HTML] Design, Synthesis and In Vivo Evaluation of a Candidate Fusion Epitopic Construct Vaccine Based on M2e, HA1, HA2, NA and NP Fragments of the Highly …

A Hamidi, H Farzin, A Haghparast - Archives of Razi Institute, 2024 - archrazi.areeo.ac.ir
The H5N1 subtype of Influenza virus, have a very high pathogenicity and lethality in humans
and animals, and the need to develop new vaccines with a wide range of effects against this …

Reverse vaccinology approach to design a novel multi-epitope subunit vaccine against avian influenza A (H7N9) virus

M Hasan, PP Ghosh, KF Azim, S Mukta, RA Abir… - Microbial …, 2019 - Elsevier
H7N9, a novel strain of avian origin influenza was the first recorded incidence where a
human was transited by a N9 type influenza virus. Effective vaccination against influenza A …

Protective immunity against homologous and heterologous influenza virus lethal challenge by immunization with new recombinant chimeric HA2-M2e fusion protein in …

A Ameghi, Y Pilehvar-Soltanahmadi, B Baradaran… - Viral …, 2016 - liebertpub.com
Influenza is an acute and highly contagious respiratory disease. The error prone RNA
polymerase and segmented nature of the influenza A virus genome allow antigenic drift and …

[HTML][HTML] Expression of HA1 antigen of H5N1 influenza virus as a potent candidate for vaccine in bacterial system

AS Farsad, S Malekzadeh-Shafaroudi… - Iranian Journal of …, 2016 - ncbi.nlm.nih.gov
The impending influenza virus pandemic requires global vaccination to prevent large-scale
mortality and morbidity, but traditional influenza virus vaccine production is too slow for rapid …

A universal epitope-based influenza vaccine and its efficacy against H5N1

Y Adar, Y Singer, R Levi, E Tzehoval, S Perk… - Vaccine, 2009 - Elsevier
Previous studies have shown that a recombinant vaccine expressing four highly conserved
influenza virus epitopes has a potential for a broad spectrum, cross-reactive vaccine; it …

Relationship between some H5 commercial vaccines and the highly pathogenic H5N8 avian influenza virus that is recently circulating in Egypt

N Bedair, A Mostafa, OA Khamiss - Research Journal of Applied …, 2023 - journals.ekb.eg
The prevalence of avian influenza viruses (AIVs) in Egypt has had a devastating effect on
the poultry sector. Here, we isolated two HPAI (H5N8) viruses from broiler poultry farms in …

A live bivalent influenza vaccine based on a H9N2 virus strain

R Wu, Y Guan, Z Yang, J Chen, H Wang, Q Chen, Z Sui… - Vaccine, 2010 - Elsevier
The purpose of this study was to construct an H9N2 virus-based bivalent live vaccine
expressing the protective antigen of a different subtype of influenza virus. Reverse genetics …

Hemagglutinin amino acids related to receptor specificity could affect the protection efficacy of H5N1 and H7N9 avian influenza virus vaccines in mice

L Xu, L Bao, SY Lau, WL Wu, J Yuan, S Gu, F Li, Q Lv… - Vaccine, 2016 - Elsevier
The continuous and sporadic human transmission of highly pathogenic avian H5N1 and
H7N9 influenza viruses illustrates the urgent need for efficacious vaccines. However, all …

[HTML][HTML] Generation of new M2e-HA2 fusion chimeric peptide to development of a recombinant fusion protein vaccine

A Ameghi, B Baradaran, K Aghaiypour… - Advanced …, 2015 - ncbi.nlm.nih.gov
Purpose: The purpose was to design a new construction containing influenza virus (H1N1)
M2e gene and HA2 gene by bioinformatics approach, cloning the construct in to Escherichia …

Development of broadly reactive H5N1 vaccine against different Egyptian H5N1 viruses

M Ibrahim, HA Sultan, AGA Razik, K Kang, AS Arafa… - Vaccine, 2015 - Elsevier
The H5N1 highly pathogenic avian influenza (HPAI) virus was isolated for the first time in
Egypt in 2006, since then, the virus has become endemic causing a significant threat to the …