Arterial bypass grafts remain the gold standard for the treatment of end-stage ischaemic
disease. Yet patients unable to tolerate the cardiovascular stress of arterial surgery or those …

Vascularization and efficient perfusion are long-standing challenges in cardiac tissue
engineering. Here we report engineered perfusable microvascular constructs, wherein …

Tissue vascularization and integration with host circulation remains a key barrier to the
translation of engineered tissues into clinically relevant therapies. Here, we used a …

The field of tissue engineering has advanced the development of increasingly biocompatible
materials to mimic the extracellular matrix of vascularized tissue. However, a majority of …

Engineering hierarchical vasculatures is critical for creating implantable functional thick
tissues. Current approaches focus on fabricating mesoscale vessels for implantation or …

The ultimate design of functionally therapeutic engineered tissues and organs will rely on
our ability to engineer vasculature that can meet tissue-specific metabolic needs. We …

Current techniques for tissue engineering blood vessels are not customizable for vascular
size variation and vessel wall thickness. These critical parameters vary widely between the …

The in vivo efficacy of engineered tissue constructs depends largely on their integration with
the host vasculature. Prevascularisation has been noted to facilitate integration of the …

Tissue engineered grafts lack adequate vascularization and suffer from poor perfusion in
vivo curtailing clinical application. Improving vascularization in any tissue implants would …

Although several strategies to three-dimensionally print cardiovascular grafts exist, these
technologies either have required extensive culturing of cells on scaffolds prior to …