Background Insulin resistance not only occurs in obesity, but also in lipodystrophy. Although
adipose tissue mass affects metabolic fluxes and participates in interorgan crosstalk, the role …

New Findings What is the topic of this review? The review covers basic knowledge about the
role of mitochondria in the homeostatic function of adipose tissue. It also provide a …

White adipose tissue is one of the largest organs of the body. It plays a key role in whole‐
body energy status and metabolism; it not only stores excess energy but also secretes …

Context: It has been suggested that mitochondrial dysfunction in adipocytes contributes to
obesity-related metabolic complications. However, obesity results in adipocyte hypertrophy …

Increasing evidence suggests that reduced adipose tissue mitochondrial content is
associated with the pathogenesis of type 2 diabetes. These investigations have utilized …

Background & Aims Adipose tissue dysfunction is involved in the development of insulin
resistance and is responsible for excessive lipid delivery to other organs such as the liver …

Although mitochondria in brown adipose tissue and their role in non-shivering
thermogenesis have been widely studied, we have only a limited understanding of the …

We present multiple findings on derangements in lipid metabolism in type 2 diabetes. The
increase in the intracellular deposition of triglycerides (TG) in muscles, liver and pancreas in …

Obesity, the major cause of the current global epidemic of type 2 diabetes (T2D), induces
insulin resistance in peripheral insulin target tissues. Several mechanisms have been …

Obesity-induced mitochondrial dysfunction in white adipose tissue (WAT) leads to a
dysregulation of adipokine secretion, which is involved in insulin resistance development …