The role of impulsivity in relapse vulnerability

T Pattij, TJ De Vries - Current opinion in neurobiology, 2013 - Elsevier
Drug dependence in humans is often accompanied by behavioral disturbances such as
maladaptive levels of impulsivity. In turn, there is accumulating evidence from preclinical …

The role of impulsive behavior in drug abuse

JL Perry, ME Carroll - Psychopharmacology, 2008 - Springer
Background Impulsivity is a multifaceted construct that has recently been recognized as a
factor contributing to enhanced vulnerability to drug abuse. Objectives In the present review …

Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models

B Jupp, JW Dalley - British journal of pharmacology, 2014 - Wiley Online Library
Research over the last two decades has widely demonstrated that impulsivity, in its various
forms, is antecedent to the development of drug addiction and an important behavioural trait …

[HTML][HTML] Recent translational findings on impulsivity in relation to drug abuse

J Weafer, SH Mitchell, H de Wit - Current addiction reports, 2014 - Springer
Impulsive behavior is strongly implicated in drug abuse, as both a cause and a
consequence of drug use. To understand how impulsive behaviors lead to and result from …

High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence

D Economidou, Y Pelloux, TW Robbins, JW Dalley… - Biological …, 2009 - Elsevier
BACKGROUND: Relapse is a hallmark feature of cocaine addiction and a main challenge
for treatment strategies. Human studies indicate a link between impulsivity and increased …

Impulsivity as a determinant and consequence of drug use: a review of underlying processes

H De Wit - Addiction biology, 2009 - Wiley Online Library
Impulsive behaviors are closely linked to drug use and abuse, both as contributors to use
and as consequences of use. Trait impulsivity is an important determinant of drug use during …

[HTML][HTML] The role of impulsivity in the aetiology of drug dependence: reward sensitivity versus automaticity

L Hogarth - Psychopharmacology, 2011 - Springer
Rationale Impulsivity has long been known as a risk factor for drug dependence, but the
mechanisms underpinning this association are unclear. Impulsivity may confer …

Trait-like impulsivity does not predict escalation of heroin self-administration in the rat

R McNamara, JW Dalley, TW Robbins, BJ Everitt… - …, 2010 - Springer
Rationale The neural and psychological mechanisms underlying vulnerability to drug
addiction are poorly understood. Although a number of animal models have been …

[HTML][HTML] Unidirectional relationship between heroin self-administration and impulsive decision-making in rats

MC Schippers, R Binnekade, ANM Schoffelmeer… - …, 2012 - Springer
Rationale There is growing clinical evidence for a strong relationship between drug
addiction and impulsivity. However, it is not fully clear whether impulsivity is a pre-existing …

[HTML][HTML] Trait impulsive choice predicts resistance to extinction and propensity to relapse to cocaine seeking: a bidirectional investigation

N Broos, L Diergaarde, ANM Schoffelmeer… - …, 2012 - nature.com
Despite the strong association between impulsivity and addiction in humans, it is still a
matter of debate whether impulsive choice predisposes to, or results from, drug …