Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors

Y Chen, J Zeng, C Zhao, K Wang, E Trood… - Archives of …, 2011 - jamanetwork.com
Objectives To evaluate the independent and joint effects of genetic factors and
environmental variables on advanced forms of age-related macular degeneration (AMD) …

Rare and common genetic variants, smoking, and body mass index: progression and earlier age of developing advanced age-related macular degeneration

JM Seddon, R Widjajahakim… - … Ophthalmology & Visual …, 2020 - iovs.arvojournals.org
Purpose: To determine behavioral and genetic factors associated with incidence and age of
progression to advanced age-related macular degeneration (AMD), geographic atrophy …

[HTML][HTML] Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables

JM Seddon, R Reynolds, J Maller… - … & visual science, 2009 - arvojournals.org
purpose. The joint effects of genetic, ocular, and environmental variables were evaluated
and predictive models for prevalence and incidence of AMD were assessed. methods …

Risk assessment model for development of advanced age-related macular degeneration

ML Klein, PJ Francis, FL Ferris, SC Hamon… - Archives of …, 2011 - jamanetwork.com
Objective To design a risk assessment model for development of advanced age-related
macular degeneration (AMD) incorporating phenotypic, demographic, environmental, and …

[HTML][HTML] Genetic risk factors and age-related macular degeneration (AMD)

M Mousavi, RA Armstrong - Journal of Optometry, 2013 - Elsevier
Age related macular degeneration (AMD) is the leading cause of blindness in individuals
older than 65 years of age. It is a multifactorial disorder and identification of risk factors …

Risk prediction for progression of macular degeneration: 10 common and rare genetic variants, demographic, environmental, and macular covariates

JM Seddon, RE Silver, M Kwong… - … ophthalmology & visual …, 2015 - iovs.arvojournals.org
Purpose.: To determine the association between genetic variants and transition to advanced
age-related macular degeneration (AMD), and to develop a predictive model and online …

A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors

DA Schaumberg, SE Hankinson, Q Guo… - Archives of …, 2007 - jamanetwork.com
Objectives To delineate the magnitude of susceptibility to age-related macular degeneration
(AMD) due to common variants in the gene for complement factor H (CFH) and the predicted …

Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes

L Sobrin, S Ripke, Y Yu, J Fagerness, TR Bhangale… - Ophthalmology, 2012 - Elsevier
PURPOSE: To investigate whether the 2 subtypes of advanced age-related macular
degeneration (AMD), choroidal neovascularization (CNV), and geographic atrophy (GA) …

The application of genetic risk scores in age-related macular degeneration: a review

JN Cooke Bailey, JD Hoffman, RJ Sardell… - Journal of clinical …, 2016 - mdpi.com
Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging,
is inarguably influenced by complex interactions between genetic and environmental …

Five-year incidence, progression, and risk factors for age-related macular degeneration: the age, gene/environment susceptibility study

F Jonasson, DE Fisher, G Eiriksdottir, S Sigurdsson… - Ophthalmology, 2014 - Elsevier
Objective To investigate the incidence and progression of age-related macular degeneration
(AMD) and associated risk factors. Design Population-based, prospective, cohort study …