OBJECTIVES: The PNPLA3 rs738409 single-nucleotide polymorphism is known to promote
nonalcoholic steatohepatitis (NASH), but its association with fibrosis severity and …

Background & Aims Subtle inter-patient genetic variation and environmental factors combine
to determine disease progression in non-alcoholic fatty liver disease (NAFLD). Carriage of …

Background An isoleucine> methionine mutation at position 148 in the PNPLA3 gene (p.
I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in …

Background & Aims Patients with nonalcoholic fatty liver disease (NAFLD) have an
increased risk for liver-related complications, such as decompensation, hepatocellular …

Objective: This meta-analysis is to investigate the relationship between the patatin-like
phospholipase domain containing 3 (PNPLA3) rs738409 polymorphism and the …

Background & Aims PNPLA3 rs738409 has been associated with an increased risk of liver‐
related events in patients with non‐alcoholic fatty liver disease (NAFLD). In this study, we …

The incidence of hepatocellular carcinoma (HCC) is increasing in Western countries.
Although several clinical factors have been identified, many individuals never develop HCC …

Introduction and aim Studies have shown that two polymorphisms were associated with
steatosis and progression of non-alcoholic fatty liver disease (NAFLD) in different …

Aim Some patients with non‐alcoholic fatty liver disease (NAFLD) develop hepatocellular
carcinoma (HCC). Patatin‐like phospholipase domain containing 3 (PNPLA3) rs738409 …

Background In a genome-wide association scan, the single-nucleotide polymorphism (SNP)
rs738409 in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with …