While many anti-cancer modalities have shown potent efficacy in clinical practices, cancer
prevention, timely detection, and effective treatment are still challenging. As a newly …

Purpose Ferroptosis is an iron-dependent and reactive oxygen species (ROS)-reliant form of
cell death, exhibiting cellular, molecular, and gene-level characteristics distinct from those of …

Background: Inducing ferroptosis in human tumors has become a potential strategy to
improve the prognosis of patients, even in those with chemotherapeutic resistance. The xCT …

Background The ferroptosis inhibitory gene Solute carrier family 7 member 11 (SLC7A11)
provides a new strategy for anticancer treatment. However, its function in renal cell …

Colorectal cancer (CRC) is one of the most lethal cancers of the digestive system. The tumor
microenvironment (TME) plays a central role in the initiation and development of CRC …

Background Solute carrier family 7 member 2 (SLC7A2), a cationic amino acid transporter, is
lowly expressed in ovarian and hepatocellular cancers, which is associated with their worse …

SLC16A family members play crucial roles in tumorigenesis and tumor progression.
However, the exact role of distinct members in the SLC16A family in human pancreatic …

Background: Ferroptosis induced by SLC7A11 has an important translational value in the
treatment of cancers. However, the mechanism of SLC7A11 in the pathogenesis of colon …

Background: SLC1A5, a ferroptosis regulator gene, plays a dual role in cancer regulation.
However, the roles of SLC1A5 in pancreatic adenocarcinoma (PAAD) remain elusive …

Solute carrier family 31 member 1 (SLC31A1) encodes a protein that functions as a
homotrimer for the uptake of dietary copper. As a vital member of the cuproptosis gene …