Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways

T Yi, SG Cho, Z Yi, X Pang, M Rodriguez, Y Wang… - Molecular cancer …, 2008 - AACR
Thymoquinone, a component derived from the medial plant Nigella sativa, has been used
for medical purposes for more than 2,000 years. Recent studies reported that thymoquinone …

[HTML][HTML] Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway

L Peng, A Liu, Y Shen, HZ Xu, SZ Yang… - Oncology …, 2013 - spandidos-publications.com
Thymoquinone (TQ), the predominant bioactive constituent derived from the medicinal spice
Nigella sativa (also known as black cumin), has been applied for medical purposes for more …

Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway

J Yang, X Kuang, P Lv, X Yan - Tumor Biology, 2015 - Springer
Thymoquinone (TQ) is the primary bioactive component of Nigella sativa Linn seed oil and
used as anti-inflammatory, anti-oxidant, and anti-neoplastic agent. Previous studies have …

Thymoquinone, an active compound of Nigella sativa: role in prevention and treatment of cancer

SA Almatroodi, A Almatroudi, MA Alsahli… - Current …, 2020 - ingentaconnect.com
Background: Cancer is the leading cause of death worldwide and the current mode of
cancer treatment causes side effects on normal cells and are still the key challenges in its' …

Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo

S Attoub, O Sperandio, H Raza, K Arafat… - Fundamental & …, 2013 - Wiley Online Library
Phytochemical compounds are emerging as a new generation of anticancer agents with
limited toxicity in cancer patients. The purpose of this study was to investigate the potential …

Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer

S Banerjee, AO Kaseb, Z Wang, D Kong… - Cancer research, 2009 - AACR
Previous studies have shown biological activity of thymoquinone, an active compound
extracted from Nigella sativa, in pancreatic cancer cells; however, preclinical animal studies …

[HTML][HTML] Thymoquinone inhibits epithelial-mesenchymal transition in prostate cancer cells by negatively regulating the TGF-β/Smad2/3 signaling pathway …

B Kou, W Liu, W Zhao, P Duan, Y Yang… - Oncology …, 2017 - spandidos-publications.com
Thymoquinone, a major ingredient of black seed oil (Nigella sativa), has been shown to
exhibit anticancer capacity in various types of cancers. However, there are few studies …

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn

MK Shanmugam, F Arfuso, AP Kumar, L Wang… - Pharmacological …, 2018 - Elsevier
Thymoquinone (TQ), isolated almost fifty years ago, is the main bioactive constituent of black
seed essential oil extracted from the seed of Nigella sativa. TQ has been shown to have …

Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species

PS Koka, D Mondal, M Schultz… - Experimental …, 2010 - journals.sagepub.com
Thymoquinone (TQ), an active ingredient of black seed oil (Nigella Sativa), has been shown
to possess antineoplastic activity against a variety of experimental tumors. However, the …

[HTML][HTML] Thymoquinone: A novel strategy to combat cancer: A review

M Imran, A Rauf, IA Khan, M Shahbaz… - Biomedicine & …, 2018 - Elsevier
The higher consumption of fruit, herbs, spices, and vegetables is well known and practical
strategy to cure human cancers owing to their presence of bioactive compounds. Among …