Galanin and spinal nociceptive mechanisms: recent advances and therapeutic implications

XJ Xu, T Hökfelt, T Bartfai, Z Wiesenfeld-Hallin - Neuropeptides, 2000 - Elsevier
Galanin is a peptide consisting of 29 or 30 (in humans) amino acids that is present in
sensory and spinal dorsal horn neurons. Endogenous galanin may have an important …

[HTML][HTML] The generation of knock-in mice expressing fluorescently tagged galanin receptors 1 and 2

N Kerr, FE Holmes, SA Hobson, P Vanderplank… - Molecular and Cellular …, 2015 - Elsevier
The neuropeptide galanin has diverse roles in the central and peripheral nervous systems,
by activating the G protein-coupled receptors Gal 1, Gal 2 and the less studied Gal 3 (GalR1 …

Regulation of galanin and neuropeptide Y in dorsal root ganglia and dorsal horn in rat mononeuropathic models: possible relation to tactile hypersensitivity

TJS Shi, JG Cui, BA Meyerson, B Linderoth, T Hökfelt - Neuroscience, 1999 - Elsevier
The expression of galanin and neuropeptide Y in rat lumbar 5 (L5) dorsal root ganglia and
dorsal horn (L4–5) was studied after four types of peripheral nerve injury using …

Galanin–25 years with a multitalented neuropeptide: galanin acts as a trophic factor to the central and peripheral nervous systems

SA Hobson, A Bacon, CR Elliot-Hunt… - Cellular and Molecular …, 2008 - Springer
The neuropeptide galanin is widely, but not ubiquitously, expressed in the adult nervous
system. Its expression is markedly upregulated in many neuronal tissues after nerve injury or …

Regulation of expression of galanin and galanin receptors in dorsal root ganglia and spinal cord after axotomy and inflammation.

XU Zhang, ZO Xu, TJ Shi, M Landry… - Annals of the New …, 1998 - europepmc.org
Galanin can normally be detected only in a few dorsal root ganglion (DRG) neurons, but it is
dramatically upregulated after peripheral nerve injury in both rat and monkey. Galanin is …

Galanin receptor-expressing dorsal horn neurons: role in nociception

LL Lemons, RG Wiley - Neuropeptides, 2011 - Elsevier
Galanin, along with enkephalins and neuropeptide Y, has been hypothesized to negatively
modulate nociception in the superficial dorsal horn of the spinal cord. In the present study …

Peripheral galanin receptor 2 as a target for the modulation of pain

RP Hulse, LF Donaldson… - Pain research and …, 2012 - Wiley Online Library
The neuropeptide galanin is widely expressed in the nervous system and has an important
role in nociception. It has been shown that galanin can facilitate and inhibit nociception in a …

Nerve injury induces plasticity that results in spinal inhibitory effects of galanin

SJL Flatters, AJ Fox, AH Dickenson - Pain, 2002 - Elsevier
Galanin is a 29-amino-acid neuropeptide that has been implicated in the processes of
nociception. This study examines the effect of exogenous galanin on dorsal horn neurone …

Galanin expression in adult human dorsal root ganglion neurons: initial observations

M Landry, K Åman, J Dostrovsky, AM Lozano… - Neuroscience, 2003 - Elsevier
Human dorsal root ganglia (DRGs) were obtained during various procedures and processed
for single and double in situ hybridisation using oligonucleotide probes complementary to …

Endogenous galanin potentiates spinal nociceptive processing following inflammation

BJ Kerr, Y Gupta, R Pope, SWN Thompson, D Wynick… - Pain, 2001 - journals.lww.com
We have undertaken a series of experiments using galanin null mutant mice to better define
the role of endogenous galanin in spinal excitability following inflammation and in response …