Endogenous galanin potentiates spinal nociceptive processing following inflammation
We have undertaken a series of experiments using galanin null mutant mice to better define
the role of endogenous galanin in spinal excitability following inflammation and in response …
the role of endogenous galanin in spinal excitability following inflammation and in response …
Galanin increases membrane excitability and enhances Ca2+ currents in adult, acutely dissociated dorsal root ganglion neurons
N Kerekes, F Mennicken, D O'Donnell… - European Journal of …, 2003 - Wiley Online Library
We examined the effect of galanin (10− 15–10− 7 m) on dispersed, mainly small‐sized
dorsal root ganglion (DRG) neurons in adult rats using whole‐cell patch‐clamp. Galanin and …
dorsal root ganglion (DRG) neurons in adult rats using whole‐cell patch‐clamp. Galanin and …
In vivo and in vitro effects of peripheral galanin on nociceptive transmission in naive and neuropathic states
SJL Flatters, AJ Fox, AH Dickenson - Neuroscience, 2003 - Elsevier
Galanin is widely distributed in the nervous system and is consistently upregulated in both
dorsal root ganglion and spinal neurones by peripheral nerve injury. This study investigates …
dorsal root ganglion and spinal neurones by peripheral nerve injury. This study investigates …
Galanin overexpressing transgenic mice
JN Crawley, EJ Mufson, JG Hohmann, D Teklemichael… - Neuropeptides, 2002 - Elsevier
Galanin overexpressing transgenic mice (GAL-tg) were generated on two different
promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and …
promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and …
[HTML][HTML] Cloning and expressional characterization of a novel galanin receptor: identification of different pharmacophores within galanin for the three galanin receptor …
S Wang, C He, T Hashemi, M Bayne - Journal of Biological Chemistry, 1997 - ASBMB
Galanin, a 29–30 amino acid neuropeptide, is found in the central and peripheral nervous
systems and displays several important physiological activities. The actions are believed to …
systems and displays several important physiological activities. The actions are believed to …
Galanin and spinal pain mechanisms: past, present, and future
XJ Xu, T Hökfelt, Z Wiesenfeld-Hallin - Galanin, 2010 - Springer
Since the discovery of galanin in 1983, one of the most frequently suggested physiological
function for this peptide is pain modulation at the level of the spinal cord. This notion, initially …
function for this peptide is pain modulation at the level of the spinal cord. This notion, initially …
Galanin acts as a trophic factor to the central and peripheral nervous systems
SA Hobson, A Bacon, CR Elliot-Hunt, FE Holmes… - Galanin, 2010 - Springer
The neuropeptide galanin is widely, but not ubiquitously, expressed in the adult nervous
system. Its expression is markedly up-regulated in many neuronal tissues after nerve injury …
system. Its expression is markedly up-regulated in many neuronal tissues after nerve injury …
Distribution of galanin-1,-2 and-3 receptor messenger RNAs in central and peripheral rat tissues
SM Waters, JE Krause - Neuroscience, 1999 - Elsevier
Galanin is a neuropeptide widely expressed in the central nervous system and periphery. In
rat, three galanin-binding receptors have been cloned and characterized. We report the …
rat, three galanin-binding receptors have been cloned and characterized. We report the …
[HTML][HTML] Effects of exogenous galanin on neuropathic pain state and change of galanin and its receptors in DRG and SDH after sciatic nerve-pinch injury in rat
X Xu, X Yang, P Zhang, X Chen, H Liu, Z Li - PloS one, 2012 - journals.plos.org
A large number of neuroanatomical, neurophysiologic, and neurochemical mechanisms are
thought to contribute to the development and maintenance of neuropathic pain. However …
thought to contribute to the development and maintenance of neuropathic pain. However …
Galanin in sensory neurons in the spinal cord.
Z Wiesenfeld-Hallin, T Bartfai… - Frontiers in …, 1992 - europepmc.org
The distribution and physiological effects of the neuropeptide galanin (GAL) have been
examined in the somatosensory system. GAL is normally present in a few sensory neurons …
examined in the somatosensory system. GAL is normally present in a few sensory neurons …