Cryo-EM structure of human heptameric pannexin 2 channel

H Zhang, S Wang, Z Zhang, M Hou, C Du… - Nature …, 2023 - nature.com
Abstract Pannexin 2 (Panx2) is a large-pore ATP-permeable channel with critical roles in
various physiological processes, such as the inflammatory response, energy production and …

Cryo-EM structure of human heptameric Pannexin 1 channel

R Qu, L Dong, J Zhang, X Yu, L Wang, S Zhu - Cell Research, 2020 - nature.com
Dear Editor, Cellular communication is crucial during basic development and in the
maintenance of homeostasis in adult organisms, and such communication involves the …

Structural and functional analysis of human pannexin 2 channel

Z He, Y Zhao, MJ Rau, JAJ Fitzpatrick, R Sah… - Nature …, 2023 - nature.com
Abstract The pannexin 2 channel (PANX2) participates in multiple physiological processes
including skin homeostasis, neuronal development, and ischemia-induced brain injury …

Structural basis for gating mechanism of Pannexin 1 channel

L Mou, M Ke, M Song, Y Shan, Q Xiao, Q Liu, J Li… - Cell research, 2020 - nature.com
Dear Editor, Pannexin 1 (PANX1) plays extensive physiological roles across diverse fields of
biology, including cell death, 1, 2 inflammation, 3 cancer progression, 4 and neurological …

Structure versus function: Are new conformations of pannexin 1 yet to be resolved?

C Mim, G Perkins, G Dahl - Journal of General Physiology, 2021 - rupress.org
Pannexin 1 (Panx1) plays a decisive role in multiple physiological and pathological settings,
including oxygen delivery to tissues, mucociliary clearance in airways, sepsis, neuropathic …

Cryo-EM structures of human pannexin 1 channel

Q Jin, B Zhang, X Zheng, N Li, L Xu, Y Xie, F Song… - Cell research, 2020 - nature.com
Dear Editor, Pannexin 1 (PANX1) channel mediates adenosine-5′-triphosphate (ATP)
release for purinergic signaling, 1 playing important roles in multiple physiological and …

Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis

S Zhang, B Yuan, JH Lam, J Zhou, X Zhou… - Cell Discovery, 2021 - nature.com
Abstract Pannexin1 (PANX1) is a large-pore ATP efflux channel with a broad distribution,
which allows the exchange of molecules and ions smaller than 1 kDa between the …

Cryo-EM structures of the ATP release channel pannexin 1

Z Deng, Z He, G Maksaev, RM Bitter, M Rau… - Nature structural & …, 2020 - nature.com
The plasma membrane adenosine triphosphate (ATP) release channel pannexin 1 (PANX1)
has been implicated in many physiological and pathophysiological processes associated …

Human Pannexin 1 channel: Insight in structure–function mechanism and its potential physiological roles

EA Bhat, N Sajjad - Molecular and Cellular Biochemistry, 2021 - Springer
Pannexins, large non-gap junction super family exists in vertebrates, play multiple roles in
different cellular functions through their ATP release. Panx1-mediated adenosine 5 …

Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids

M Kuzuya, H Hirano, K Hayashida, M Watanabe… - Science …, 2022 - science.org
Pannexin (PANX) family proteins form large-pore channels that mediate purinergic
signaling. We analyzed the cryo-EM structures of human PANX1 in lipid nanodiscs to …