It has previously been shown that murine sarcoma cells express high-affinity IL-4 receptors
(1L-4R) which are internalized after binding to the ligand (Puri et al., Cancer Res 1991; 51 …

Previously, Puri et al.(Puri, RK, M. Ogata, P. Leland, GM Feldman, D. Fitzgerald, and I.
Pastan. 1991. Cancer Res. 51: 3011-3017) have demonstrated that murine sarcoma and …

Abstract Interleukin (IL)-4 is a crucial cytokine in tumor immunology. In the initial murine
experiments, IL-4 exhibited potent anti-tumor ability. Tumors genetically modified to produce …

We have reported that human malignant glioma cell lines express high levels of plasma
membrane interleukin-4 receptors (IL-4R). We have also reported that biopsy/surgical …

Melanoma cells can secrete several cytokines and express various cell surface molecules,
such as the intercellular adhesion molecule ICAM-1, class II histocompatibility antigens, and …

Several human head and neck squamous carcinoma cell lines were found to bind 125I-
labeled or fluorescein-labeled interleukin 2 (IL-2). This binding was inhibited by an excess of …

Despite advances in diagnosis and treatment, survival rates for patients with head and neck
cancer have remained unchanged for the last 30 years. In an attempt to develop novel …

The expression of the interleukin 4 (IL-4) receptor (IL-4R) and effects of human recombinant
IL-4 on human gastric carcinoma cell lines were studied. We demonstrated that IL-4 …

We have previously reported on the expression of interleukin-4 receptors (IL-4R) on many
human epithelial cancer cells; however, the binding characteristics, structure, function, and …

Interleukin 13 receptor α2 (IL-13Rα2) chain is highly expressed on some tumor cell lines
and primary cell cultures. This receptor chain plays an important role in ligand binding and …