Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

C Bär, S Chatterjee, I Falcão Pires… - Cardiovascular …, 2020 - academic.oup.com
Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-
coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs …

[HTML][HTML] The noncoding-RNA landscape in cardiovascular health and disease

V Di Mauro, M Barandalla-Sobrados… - Non-coding RNA …, 2018 - Elsevier
The cardiovascular system plays a pivotal role in regulating and maintaining homeostasis in
the human body. Therefore any alteration in regulatory networks that orchestrate heart …

Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease

A Caporali, M Anwar, Y Devaux, R Katare… - Nature Reviews …, 2024 - nature.com
The adult heart is a complex, multicellular organ that is subjected to a series of regulatory
stimuli and circuits and has poor reparative potential. Despite progress in our understanding …

Non-coding RNAs: the “dark matter” of cardiovascular pathophysiology

C Iaconetti, C Gareri, A Polimeni, C Indolfi - International Journal of …, 2013 - mdpi.com
Large-scale analyses of mammalian transcriptomes have identified a significant number of
different RNA molecules that are not translated into protein. In fact, the use of new …

Non-coding RNAs: emerging players in cardiomyocyte proliferation and cardiac regeneration

N Abbas, F Perbellini, T Thum - Basic Research in Cardiology, 2020 - Springer
Soon after birth, the regenerative capacity of the mammalian heart is lost, cardiomyocytes
withdraw from the cell cycle and demonstrate a minimal proliferation rate. Despite improved …

Long non-coding RNAs: at the heart of cardiac dysfunction?

L Hobuß, C Bär, T Thum - Frontiers in physiology, 2019 - frontiersin.org
During the past decade numerous studies highlighted the importance of long non-coding
RNAs (lncRNAs) in orchestrating cardiovascular cell signaling. Classified only by a …

Non‐coding RNAs: key players in cardiac disease

FP Kreutzer, J Fiedler, T Thum - The Journal of physiology, 2020 - Wiley Online Library
Molecular mechanisms underlying heart failure (HF) are only partly understood. Non‐coding
RNAs (ncRNAs) have been reported to control function and signalling routes in the …

Deciphering non-coding RNAs in cardiovascular health and disease

A Das, A Samidurai, FN Salloum - Frontiers in cardiovascular …, 2018 - frontiersin.org
After being long considered as “junk” in the human genome, non-coding RNAs (ncRNAs)
currently represent one of the newest frontiers in cardiovascular disease (CVD) since they …

Regulation of long non-coding RNAs and microRNAs in heart disease: insight into mechanisms and therapeutic approaches

L Collins, P Binder, H Chen, X Wang - Frontiers in Physiology, 2020 - frontiersin.org
Cardiovascular disease is the leading cause of mortality worldwide and there is an
increasing need to identify new therapeutic targets that could be used to prevent or treat …

Extracellular non-coding RNAs in cardiovascular diseases

Z Jiapaer, C Li, X Yang, L Sun, E Chatterjee, L Zhang… - Pharmaceutics, 2023 - mdpi.com
Cardiovascular diseases (CVDs) remain the world's leading cause of death despite the best
available healthcare and therapy. Emerging as a key mediator of intercellular and inter …