In neuronal and atrial tissue, G protein-gated inwardly rectifying K+ channels (Kir3. x family)
are responsible for mediating inhibitory postsynaptic potentials and slowing the heart rate …

G protein-gated inwardly rectifying K+ (Kir) channels are found in neurones, atrial myocytes,
and endocrine cells and are involved in generating late inhibitory postsynaptic potentials …

Guanine nucleotide-binding proteins (G proteins) activate K+ conductances in cardiac atrial
cells to slow heart rate and in neurons to decrease excitability. cDNAs encoding three …

G proteins, particularly those sensitive to pertussis toxin, are difficult to separate
biochemically, creating uncertainty in functional assignments. For this reason the cDNAs …

Activation of G protein-gated K÷ channels by G protein-coupled receptors contributes to
parasympathetic regulation of heart rate in the atrium and inhibitory postsynaptic potentials …

The cardiac G protein-gated K+ channel, I KACh, is activated by application of purified and
recombinant β and γ subunits (Gβγ) of heterotrimeric G proteins to excised inside-out …

Cardiac and neuronal G protein-activated K+ channels (GIRK; Kir3) open following the
binding of Gβγ subunits, released from G i/o proteins activated by neurotransmitters. GIRKs …

Gβγ subunits are known to bind to and activate G-protein-activated inwardly rectifying K+
channels (GIRK) by regulating their open probability and bursting behavior. Studying G …

G protein-gated inward rectifier K+ (GIRK) channels mediate hyperpolarizing postsynaptic
potentials in the nervous system and in the heart during activation of Gα (i/o)-coupled …

G protein-coupled inwardly rectifying potassium (GIRK) channels can be activated or
inhibited by different classes of receptors, suggesting a role for G proteins in determining …