Currently, an in vivo model of human breast cancer metastasizing from the orthotopic site to
bone does not exist, making it difficult to study the many steps of skeletal metastasis …

Breast cancer affects approximately one woman in twelve and kills more women than any
other cancer. If detected early, patients have a five year survival rate of 66%, but once …

Bone metastases cause significant morbidity and mortality in late-stage breast cancer
patients and are currently considered incurable. Investigators rely on translational models to …

Bone is one of the most preferential target sites for cancer metastasis. Breast cancer has a
predilection for spreading to bone, and bone metastasis is one of the major causes of …

In practice, investigations for bone metastasis of breast cancer rely heavily on models in
vivo. Lacking of such ideal model makes it difficult to study the whole process or accurate …

Breast cancer metastasizes to bone with high frequency and incidence. However, studies of
breast cancer metastasis to bone have been limited by two factors. First, the number of …

BACKGROUND Animal models are important tools to investigate the pathogenesis and
develop treatment strategies for bone metastases in humans. However, there are few …

The skeleton is a preferred homing site for breast cancer metastasis. To date, treatment
options for patients with bone metastases are mostly palliative and the disease is still …

Metastasis of breast cancer cells to bone consists of multiple sequential steps. To
accomplish the process of metastasis to bone, breast cancer cells are required to …

Breast cancer patients with advanced disease exhibit bone metastases, leading to the
formation of osteolytic lesions for which the only currently available treatments are palliative …