Current challenges and recent developments in mass spectrometry–based metabolomics

SL Collins, I Koo, JM Peters, PB Smith… - Annual review of …, 2021 - annualreviews.org
High-resolution mass spectrometry (MS) has advanced the study of metabolism in living
systems by allowing many metabolites to be measured in a single experiment. Although …

Mass spectrometry-based technologies for high-throughput metabolomics

J Han, R Datla, S Chan, CH Borchers - Bioanalysis, 2009 - Taylor & Francis
The metabolome is composed of a vast number of small-molecule metabolites that exhibit a
diversity of physical and chemical properties and exist over a wide dynamic range in …

Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

S Alseekh, A Aharoni, Y Brotman, K Contrepois… - Nature …, 2021 - nature.com
Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However …

Advances in mass spectrometry-based metabolomics for investigation of metabolites

JL Ren, AH Zhang, L Kong, XJ Wang - RSC advances, 2018 - pubs.rsc.org
Metabolomics is the systematic study of all the metabolites present within a biological
system, which consists of a mass of molecules, having a variety of physical and chemical …

Technical challenges in mass spectrometry-based metabolomics

F Matsuda - Mass spectrometry, 2016 - jstage.jst.go.jp
Metabolomics is a strategy for analysis, and quantification of the complete collection of
metabolites present in biological samples. Metabolomics is an emerging area of scientific …

Overview of mass spectrometry-based metabolomics: opportunities and challenges

GAN Gowda, D Djukovic - Mass Spectrometry in Metabolomics: Methods …, 2014 - Springer
The field of metabolomics has witnessed an exponential growth in the last decade driven by
important applications spanning a wide range of areas in the basic and life sciences and …

Metabolite identification and quantitation in LC-MS/MS-based metabolomics

JF Xiao, B Zhou, HW Ressom - TrAC Trends in Analytical Chemistry, 2012 - Elsevier
Metabolomics aims at detection and quantitation of all metabolites in biological samples.
The presence of metabolites with a wide variety of physicochemical properties and different …

Chemical discovery in the era of metabolomics

M Sindelar, GJ Patti - Journal of the American Chemical Society, 2020 - ACS Publications
Untargeted metabolomics aims to quantify the complete set of metabolites within a biological
system, most commonly by liquid chromatography/mass spectrometry (LC/MS). Since nearly …

Mass spectrometry strategies in metabolomics

Z Lei, DV Huhman, LW Sumner - Journal of Biological Chemistry, 2011 - ASBMB
MS has evolved as a critical component in metabolomics, which seeks to answer biological
questions through large-scale qualitative and quantitative analyses of the metabolome. MS …

Eight key rules for successful data‐dependent acquisition in mass spectrometry‐based metabolomics

E Defossez, J Bourquin, S von Reuss… - Mass Spectrometry …, 2023 - Wiley Online Library
In recent years, metabolomics has emerged as a pivotal approach for the holistic analysis of
metabolites in biological systems. The rapid progress in analytical equipment, coupled to the …