Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression

SK Baisley, QZ Bremer, VP Bakshi… - Journal of …, 2014 - Soc Neuroscience
Amylin is a calcitonin-related peptide co-secreted with insulin, which produces satiety
through brainstem-localized receptors; however, its effects in forebrain are poorly …

[HTML][HTML] Amylin receptor signaling in the nucleus accumbens negatively modulates μ-opioid-driven feeding

SK Baisley, BA Baldo - Neuropsychopharmacology, 2014 - nature.com
Amylin is a peptide co-secreted with insulin that penetrates into the brain, and produces
satiation-like effects via actions in the brainstem, hypothalamus, and mesencephalon. Little …

Whole‐brain mapping of amylin‐induced neuronal activity in receptor activity–modifying protein 1/3 knockout mice

G Skovbjerg, U Roostalu, HH Hansen… - European Journal of …, 2021 - Wiley Online Library
The pancreatic hormone amylin plays a central role in regulating energy homeostasis and
glycaemic control by stimulating satiation and reducing food reward, making amylin receptor …

[HTML][HTML] Amylin modulates the mesolimbic dopamine system to control energy balance

EG Mietlicki-Baase, DJ Reiner, JJ Cone… - …, 2015 - nature.com
Amylin acts in the CNS to reduce feeding and body weight. Recently, the ventral tegmental
area (VTA), a mesolimbic nucleus important for food intake and reward, was identified as a …

[HTML][HTML] Amylin brain circuitry

L Boccia, S Gamakharia, B Coester, L Whiting, TA Lutz… - Peptides, 2020 - Elsevier
Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in
response to a meal but amylin is also produced by brain cells in discrete brain areas albeit …

Amylin acts in the lateral dorsal tegmental nucleus to regulate energy balance through gamma-aminobutyric acid signaling

DJ Reiner, EG Mietlicki-Baase, DR Olivos… - Biological …, 2017 - Elsevier
Background The pancreatic-and brain-derived hormone amylin promotes negative energy
balance and is receiving increasing attention as a promising obesity therapeutic. However …

Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior

BA Baldo, AE Kelley - American Journal of Physiology …, 2001 - journals.physiology.org
Amylin, a calcitonin gene-related peptide-like peptide coreleased with insulin, exerts
anorexic effects on central administration. Because previous studies revealed dense amylin …

Palatable food access impacts expression of amylin receptor components in the mesocorticolimbic system

H Nashawi, TJ Gustafson… - Experimental …, 2020 - Wiley Online Library
New Findings What is the central question of this study? We tested whether intra‐nucleus
accumbens core amylin receptor (AmyR) activation suppresses feeding and evaluated …

[HTML][HTML] Effects of sub-chronic amylin receptor activation on alcohol-induced locomotor stimulation and monoamine levels in mice

AL Kalafateli, C Aranäs, E Jerlhag - Psychopharmacology, 2020 - Springer
Rationale Amylin receptors consist of the calcitonin receptor (CTR) and one of three receptor
activity-modifying proteins (RAMPs). The identification of amylin receptors in areas …

[HTML][HTML] Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake

EG Mietlicki-Baase, LE Rupprecht, DR Olivos… - …, 2013 - nature.com
The ability of amylin, a pancreatic β-cell-derived neuropeptide, to promote negative energy
balance has been ascribed to neural activation at the area postrema. However, despite …