Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is
one of the leading causes of chronic pain and is increasing in prevalence in accordance …

Pain is the defining symptom of osteoarthritis (OA), yet available treatment options, of which
NSAIDs are the most common, provide inadequate pain relief and are associated with …

Abstract Purpose of Review Osteoarthritis (OA) is the most common form of arthritis and a
major source of pain and disability worldwide. OA-associated pain is usually refractory to …

OA is a painful joint disease that predominantly affects the elderly. Pain is the primary
symptom of OA, and it can present as either intermittent or constant. OA pain mechanisms …

Bidirectional interactions between the immune system and the nervous system are
increasingly appreciated as playing a pathogenic role in chronic pain. Unraveling the …

Pain is a major clinical problem of osteoarthritis (OA). Recently, OA has been thought to be a
disease of the whole joint with both destruction of cartilage and inflammatory components …

All experimental models of osteoarthritis (OA)-like joint damage are accompanied by
behaviors indicative of pain. In experimental knee OA, evoked pain responses to …

OA is a chronic arthritic disease characterized by pain, local tissue damage and attempts at
tissue repair. Historically, cartilage damage was believed to be the hallmark of OA. However …

Objectives Osteoarthritis (OA) is the leading cause of musculoskeletal pain and functional
disability worldwide, affecting a growing number of individuals in the western society …

There are over 100 different types of arthritis and each can differ greatly in their aetiology
and pathophysiology; however, one characteristic that is common to all arthritic conditions is …