Phosphatidylinositol (PI) 3-kinase is a cytoplasmic signaling molecule recruited to the
membrane by activated growth factor receptors. The p85 subunit of PI 3-kinase links the …

Abstract Phosphatidylinositol (PI) 3-kinase is a heterodimer consisting of an 85-kDa subunit
(p85) and 110-kDa subunit (p110). The 85-kDa noncatalytic subunit, which contains two Src …

Abstract Phosphatidylinositol 3-kinase (PI 3-kinase) has been implicated as a participant in
signaling pathways regulating cell growth by virtue of its activation in response to various …

Previous studies have suggested that the two subunits of phosphatidylinositol (PI) 3-kinase,
p85 and p110, function as localizing and catalytic subunits, respectively. Using recombinant …

Domains of interaction between the p85 and p110 subunits of phosphatidylinositol 3-kinase
(PI 3-kinase) were studied with the yeast two-hybrid expression system. A gene fusion …

Phosphatidylinositol 3-kinase, which is composed of a 110-kDa catalytic subunit and a
regulatory subunit, plays important roles in various cellular signaling mechanisms. We …

One potentially important mechanism for regulating class Ia phosphoinositide 3-kinase (PI 3-
kinase) activity is autophosphorylation of the p85α adapter subunit on Ser608 by the intrinsic …

Phosphatidylinositol (PI) 3-kinases catalyze the formation of 3′-phosphoinositides, which
appear to promote cellular responses to growth factors and such membrane trafficking …

Phosphatidylinositol 3-kinase (PI 3-kinase) is stimulated by association with a variety of
tyrosine kinase receptors and intracellular tyrosine-phosphorylated substrates. We isolated …

The PIK3CA gene encoding the p110α subunit of Class IA phosphatidylinositol 3-kinases
(PI3Ks) is frequently mutated in human tumors. Mutations in the PIK3CB gene encoding …