FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution
W Enard - Current opinion in neurobiology, 2011 - Elsevier
PURPOSE OF THE REVIEW: A reduced dosage of the transcription factor FOXP2 leads to
speech and language impairments probably owing to deficits in cortical and subcortical …
speech and language impairments probably owing to deficits in cortical and subcortical …
[HTML][HTML] A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution due to effects on aspects of speech …
have been positively selected during human evolution due to effects on aspects of speech …
Humanized Foxp2 specifically affects cortico-basal ganglia circuits
It has been proposed that two amino acid substitutions in the transcription factor FOXP2
have been positively selected during human evolution and influence aspects of speech and …
have been positively selected during human evolution and influence aspects of speech and …
An evolutionary perspective on FoxP2: strictly for the birds?
C Scharff, S Haesler - Current opinion in neurobiology, 2005 - Elsevier
FoxP2 mutations in humans are associated with a disorder that affects both the
comprehension of language and its production, speech. This discovery provided the first …
comprehension of language and its production, speech. This discovery provided the first …
Dissection of molecular mechanisms underlying speech and language disorders
SE Fisher - Applied Psycholinguistics, 2005 - cambridge.org
Developmental disorders affecting speech and language are highly heritable, but very little
is currently understood about the neuromolecular mechanisms that underlie these traits …
is currently understood about the neuromolecular mechanisms that underlie these traits …
Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain
E Spiteri, G Konopka, G Coppola, J Bomar… - The American Journal of …, 2007 - cell.com
Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the
only known cause of developmental speech and language disorders in humans. To date …
only known cause of developmental speech and language disorders in humans. To date …
FOXP2 as a molecular window into speech and language
Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome
characterized by impaired speech development and linguistic deficits. Recent genomic …
characterized by impaired speech development and linguistic deficits. Recent genomic …
FoxP2 regulates neurogenesis during embryonic cortical development
D Tsui, JP Vessey, H Tomita, DR Kaplan… - Journal of …, 2013 - Soc Neuroscience
The transcription factor FoxP2 has been associated with the development of human speech
but the underlying cellular function of FoxP2 is still unclear. Here we provide evidence that …
but the underlying cellular function of FoxP2 is still unclear. Here we provide evidence that …
Birdsong decreases protein levels of FoxP2, a molecule required for human speech
Cognitive and motor deficits associated with language and speech are seen in humans
harboring FOXP2 mutations. The neural bases for FOXP2 mutation-related deficits are …
harboring FOXP2 mutations. The neural bases for FOXP2 mutation-related deficits are …