The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions

BM Beckmann, A Castello, J Medenbach - Pflügers Archiv-European …, 2016 - Springer
Post-transcriptional regulation of gene expression plays a critical role in almost all cellular
processes. Regulation occurs mostly by RNA-binding proteins (RBPs) that recognise RNA …

From parts lists to functional significance—RNA–protein interactions in gene regulation

C Kilchert, K Sträßer, V Kunetsky… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Hundreds of canonical RNA binding proteins facilitate diverse and essential RNA
processing steps in cells forming a central regulatory point in gene expression. However …

A brave new world of RNA-binding proteins

MW Hentze, A Castello, T Schwarzl… - Nature reviews Molecular …, 2018 - nature.com
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …

Regulatory non-coding RNAs: everything is possible, but what is important?

JK Guo, M Guttman - nature methods, 2022 - nature.com
In recent years, the number of annotated noncoding RNAs (ncRNAs) and RNA-binding
proteins (RBPs) has increased dramatically. The wide range of RBPs identified highlights …

Comprehensive identification of RNA-binding proteins by RNA interactome capture

A Castello, R Horos, C Strein, B Fischer… - Post-Transcriptional …, 2016 - Springer
RNA associates with RNA-binding proteins (RBPs) from synthesis to decay, forming
dynamic ribonucleoproteins (RNPs). In spite of the preeminent role of RBPs regulating RNA …

Comprehensive identification of RNA-binding domains in human cells

A Castello, B Fischer, CK Frese, R Horos, AM Alleaume… - Molecular cell, 2016 - cell.com
Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of
these employing unknown modes of RNA binding. We developed RBDmap to determine the …

Engineering RNA‐binding proteins with diverse activities

H Wei, Z Wang - Wiley Interdisciplinary Reviews: RNA, 2015 - Wiley Online Library
With generations of efforts to understand RNA functions in diverse cellular processes, RNA‐
binding proteins (RBPs) have emerged to be one of the central players in regulating RNA …

[HTML][HTML] Ribonomic approaches to study the RNA-binding proteome

C Faoro, SF Ataide - FEBS letters, 2014 - Elsevier
Gene expression is controlled through a complex interplay among mRNAs, non-coding
RNAs and RNA-binding proteins (RBPs), which all assemble along with other RNA …

[HTML][HTML] RNA-binding proteins and post-transcriptional gene regulation

T Glisovic, JL Bachorik, J Yong, G Dreyfuss - FEBS letters, 2008 - Elsevier
RNAs in cells are associated with RNA-binding proteins (RBPs) to form ribonucleoprotein
(RNP) complexes. The RBPs influence the structure and interactions of the RNAs and play …

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

BM Beckmann, R Horos, B Fischer, A Castello… - Nature …, 2015 - nature.com
RNA-binding proteins (RBPs) exert a broad range of biological functions. To explore the
scope of RBPs across eukaryotic evolution, we determined the in vivo RBP repertoire of the …