Costimulatory molecules of the CD28 family on T lymphocytes integrate cues from innate
immune system sensors and modulate activation responses in conventional CD4+ T cells …

CD80 and CD86 are expressed on antigen presenting cells and are required to engage
their shared receptor, CD28, for the costimulation of CD4 T cells. It is unclear why two …

Activated in immune responses, T lymphocytes differentiate into effector cells with potent
immune function. CD28 is the most prominent costimulatory receptor for T‐cell activation …

ABSTRACT A subpopulation of T cells harbors a suppressor phenotype and can
significantly dampen autoreactive CD4+ and CD8+ T-cell responses. These regulatory T …

Many studies have shown the central importance of the co-receptors CD28, inducible
costimulatory molecule (ICOS) and cytotoxic T lymphocyte antigen 4 (CTLA4) in the …

Signals generated by T cell receptor (TCR) and CD28 engagement are required for optimal
T cell activation, but how these signals integrate within the cell is still largely unknown. We …

T-cells play a key role within the adaptive immune system mediating cellular immunity and
orchestrating the immune response as a whole. Their activation requires not only …

Costimulatory signals are required for priming and activation of naive T cells, while it is less
clear how they contribute to induction of regulatory T (Treg)‐cell activity. We previously …

T cell activation is initiated upon ligand engagement of the T cell receptor (TCR) and
costimulatory receptors. The CD28 molecule acts as a major costimulatory receptor in …

CD28 plays crucial costimulatory roles in T cell proliferation, cytokine production, and
germinal center response. Mice that are deficient in the inducible costimulator (ICOS) also …