Pro-inflammatory activation of vascular endothelium is implicated in pathogenesis of severe
conditions including stroke, infarction and sepsis. We have recently reported that superoxide …

Controlled endothelial delivery of SOD may alleviate abnormal local surplus of superoxide
involved in ischemia-reperfusion, inflammation and other disease conditions. Targeting SOD …

Elevated generation of reactive oxygen species (ROS) by endothelial enzymes, including
NADPH-oxidase, is implicated in vascular oxidative stress and endothelial proinflammatory …

Endothelial dysfunction/activation underlies the development of long-term cardiovascular
complications and atherosclerosis. The aim of this study was to examine a direct role for …

After an ischemic episode, reperfusion causes profound oxidative stress in the vasculature
of the afflicted tissue/organ. The dysregulated accumulation of reactive oxygen species …

Abstract Superoxide (O 2•−) promotes neointimal hyperplasia following arterial injury.
Conversely, nitric oxide (• NO) inhibits neointimal hyperplasia through various cell-specific …

Excessive production of reactive oxygen species (ROS) after cerebral ischemia and
reperfusion is implicated in brain damage through different cellular and molecular …

Reactive oxygen species, such as superoxide anion (O2−) and H2O2, cause oxidative
stress in endothelial cells, a condition implicated in the pathogenesis of many …

COMMENT tumor necrosis factor (TNF-) and interleukin 1 (IL-1) by 80% and tissue damage
in this acute model of joint inflammation. Interestingly, although the concentration of …

Neovascularization is an important physiological repair mechanism in response to ischemic
injury, and its process is dependent on reactive oxygen species (ROS). Overproduction of …