We evaluated cell-mediated immune (CMI) responses in mice given a pulmonary infection
with a Cryptococcus neoformans strain engineered to produce the Th1-type cytokine gamma …

Alternative macrophage activation is associated with exacerbated disease in murine models
of pulmonary cryptococcosis. The present study evaluated the efficacy of interferon-γ …

Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
pneumonia and meningoencephalitis in immune compromised individuals. Previous studies …

Experimental pulmonary Cryptococcus neoformans infection in BALB/c mice is associated
with polarized Th2-type cytokine production, alternative macrophage activation, and severe …

Mice with a null deletion mutation in the gamma interferon (IFN-γ) receptor gene were used
to study the role of IFN-γ responsiveness during experimental pulmonary cryptococcosis …

In the present study. the role of interferon-γ (IFN-γ) in the host resistance against
Cryptococcus neoformans was examined using a murine model of pulmonary and …

Cryptococcosis, caused by Cryptococcus neoformans, has been demonstrated to be
controlled by T helper (Th) 1 cells while Th2 cells are associated with fungal growth and …

We examined the role of interleukin (IL)-4 in host resistance against infection with
Cryptococcus neoformans. First, we examined the effects of a neutralizing anti-IL-4 …

The pathogenesis of pulmonary Cryptococcus neoformans infection and the efficacy of
passive immunoglobulin G1 (IgG1) administration were investigated in B-cell-deficient and …

The fungal pathogen Cryptococcus neoformans causes approximately one million cases of
cryptococcosis per year in people with AIDS. In contrast, the related species C. gattii is …