Lymphocytes constitute a critical component of host defenses against cryptococcosis.
Previously, we demonstrated that human lymphocytes cultured with interleukin-2 formed …

Abstract Using interleukin (IL)-18 deficient (IL-18−/−) mice, we examined the role of IL-18 in
the host resistance and Th1 response against infection with Cryptococcus neoformans …

Cryptococcal meningitis is the most common cause of meningitis among HIV/AIDS patients
in sub-Saharan Africa, and worldwide causes over 223,000 cases leading to more than …

Cryptococcosis, an increasingly important opportunistic infection caused by the
encapsulated yeast-like organism Cryptococcus neoformans, is limited by an …

Cryptococcus neoformans is an encapsulated fungus that is a major cause of meningitis in
patients with AIDS. In immunocompetent mice, administration of IgG1 mAb protects against …

In the Damage-response framework of microbial pathogenesis, infectious diseases are one
outcome of a host-microorganism interaction in a susceptible host. In cryptococcal disease …

The primary clinical manifestation of Cryptococcus neoformans infection in humans is
meningoencephalitis. To study the defense mechanisms that participate in the host …

The importance of cell-mediated immunity (CMI) and CD4+ T lymphocytes in host resistance
against Cryptococcus neoformans is well documented and is exemplified by the high …

Changes in airway dynamics have been reported in the rat model of pulmonary
cryptococcosis. However, it is not known if Cryptococcus neoformans-induced changes in …

OBJECTIVES: To characterize the pathogenicity of 15 strains of Cryptococcus neoformans
belonging to several serotype/mating type allele patterns (Dα, Da, Aα, Aa, Aα/Da and Dα/Aa) …