Abstract Background. Although Cryptococcus neoformans is a fungal pathogen that causes
human disease predominantly in the immunocompromised host, severe cryptococcal …

Bruton's tyrosine kinase (Btk) is a signaling molecule that plays important roles in B-1 B cell
development and innate myeloid cell functions and has recently been identified as a target …

We investigated the role of TNF-α in the host defence mechanism against infection with a
virulent strain of Cryptococcus neoformans. Administration of exogenous recombinant …

The effect of recombinant interferon-ã (rIFN-ã) on Cryptococcus neoformans infection was
investigated in vivo. BALB/c mice were injected intravenously with 2'd7 106 C. neoformans …

The protective efficacy of mAbs to Cryptococcus neoformans glucuronoxylomannan
depends on Ab isotype. Previous studies in A/JCr and C57BL/6J mice showed relative …

The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in
immune compromised individuals. This pathogen is typically acquired via inhalation, and …

Cryptococcus neoformans is a frequent opportunistic infectious agent in patients with
decreased T-lymphocyte-mediated immune function, including those with acquired immune …

The antiviral activities of type I IFNs have long been established. However, comparatively
little is known of their role in defenses against nonviral pathogens. We examined here the …

Cryptococcosis, an increasingly important opportunistic infection caused by the
encapsulated yeast-like organism Cryptococcus neoformans, is limited by an …

Lymphocytes constitute a critical component of host defenses against cryptococcosis.
Previously, we demonstrated that human lymphocytes cultured with interleukin-2 formed …