Comprehensive genomic profiling is a next-generation sequencing approach used to detect
several known and emerging genomic alterations. Many genomic variants detected by …

Identification of driver mutations in lung adenocarcinoma has led to development of targeted
agents that are already approved for clinical use or are in clinical trials. Therefore, the …

Lung neoplasms are the main source of death around the world. Non-small cell lung cancer
(NSCLC) constitutes over 80% of all lung malignancies and the majority of patients present …

Lung cancer is the leading cause of death for malignancy worldwide. Its molecular profiling
has enriched our understanding of cancer initiation and progression and has become …

The rapid development of targeted therapies has enormously changed the clinical
management of lung cancer patients over the past decade; therefore, molecular testing …

Lung cancer is a heterogeneous and complex disease. Genomic and transcriptomic profiling
of lung cancer not only further our knowledge about cancer initiation and progression, but …

Background Treatment of lung cancer is getting more personalized nowadays and medical
practitioners are moving away from conventional histology-driven empirical treatments …

Lung cancer is characterized by accumulation of oncogene activation, inactivation of tumor
suppressor genes and alteration of epigenetic changes. Fortunately, the past decade has …

Increasing understanding of genomic changes in cancer is transforming the diagnosis and
treatment of a subset of lung cancers. A significant proportion of lung adenocarcinomas …

Lung cancer is the leading cause of cancer mortality worldwide. Over the past decades, the
management of advanced stage lung cancer has been revolutionized from very limited …