Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology

CD Fuchs, M Trauner - Nature reviews Gastroenterology & hepatology, 2022 - nature.com
Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

Molecular physiology of bile acid signaling in health, disease, and aging

A Perino, H Demagny… - Physiological …, 2021 - journals.physiology.org
Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

W Jia, Y Li, KCP Cheung, X Zheng - Science China Life Sciences, 2024 - Springer
Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid
and glucose metabolism and immune homeostasis. Through the enterohepatic circulation …

Bile acids in glucose metabolism in health and disease

H Shapiro, AA Kolodziejczyk, D Halstuch… - Journal of Experimental …, 2018 - rupress.org
Bile acids (BAs) are cholesterol-derived metabolites that facilitate the intestinal absorption
and transport of dietary lipids. Recently, BAs also emerged as pivotal signaling molecules …

Bile acids as regulators of hepatic lipid and glucose metabolism

M Trauner, T Claudel, P Fickert, T Moustafa… - Digestive …, 2010 - karger.com
Besides their well-established roles in dietary lipid absorption and cholesterol homeostasis,
bile acids (BA) also act as metabolically active signaling molecules. The flux of reabsorbed …

therapeutic aspects of bile acid signalling in the gut‐liver axis

B Simbrunner, M Trauner… - Alimentary Pharmacology …, 2021 - Wiley Online Library
Background Bile acids are important endocrine modulators of intestinal and hepatic
signalling cascades orchestrating critical pathophysiological processes in various liver …

Endocrine functions of bile acids

SM Houten, M Watanabe, J Auwerx - The EMBO journal, 2006 - embopress.org
Bile acids (BAs), a group of structurally diverse molecules that are primarily synthesized in
the liver from cholesterol, are the chief components of bile. Besides their well‐established …

Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases

T Yang, GJ Khan, Z Wu, X Wang, L Zhang, Z Jiang - Drug Discovery Today, 2019 - Elsevier
Highlights•Cholestatic liver diseases and bile acid homeostasis are closely
connected.•Numerous signaling molecules are associated with bile acid transporters, tight …

[HTML][HTML] Intestinal bile acid physiology and pathophysiology

O Martínez-Augustin, FS de Medina - World journal of …, 2008 - ncbi.nlm.nih.gov
Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as
tensioactives, due to their amphipathic characteristics. BAs are reabsorbed very efficiently by …

[HTML][HTML] Bile acid transporters and regulatory nuclear receptors in the liver and beyond

E Halilbasic, T Claudel, M Trauner - Journal of hepatology, 2013 - Elsevier
Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation
where BAs exert their multiple physiological functions including stimulation of bile flow …