Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the CNS. Although
CD4+ T cells are implicated in MS pathogenesis and have been the main focus of MS …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS)
characterized by plaques of infiltrating CD4+ and CD8+ T cells. Studies of MS and …

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system (CNS). MS is thought to be T-cell-mediated, with prior research predominantly …

We review the contribution made by CD8+ T cells to inflammation in the central nervous
system (CNS) in Multiple Sclerosis (MS), and discuss their role in the animal model …

B cells are increasingly regarded as integral to the pathogenesis of multiple sclerosis, in part
as a result of the success of B cell–depletion therapy. Multiple B cell–dependent …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) of putative autoimmune origin. Recent evidence indicates that MS …

Strong evidence supports that CNS-specific CD4+ T cells are central to the pathogenesis of
multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Using a model of …

Multiple sclerosis (MS) is caused by T cells that are reactive for brain antigens. In
experimental autoimmune encephalomyelitis, the animal model for MS, myelin-reactive T …

Myelin presentation to T cells in the central nervous system (CNS) sustains inflammation in
multiple sclerosis (MS). CD4+ and CD8+ T cells contribute to MS, but only cells that present …

The etiology of multiple sclerosis (MS) remains unknown. However, both genetic and
environmental factors play important roles in its pathogenesis. While demyelination of axons …